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Development and Bioavailability Assessment of an Estriol-Containing Vaginal Hydrogel.
Gels
December 2024
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary.
Genitourinary syndrome of menopause (GSM) affects a significant percentage of postmenopausal women and manifests as vaginal dryness, irritation, and urinary discomfort, typically treated with vaginal estrogens. Hydrogels are preferred over creams due to their superior comfort and mucoadhesive properties. This study introduces a novel vaginal gel formulation containing hydroxyethyl cellulose (HEC) and estriol-hydroxypropyl-β-cyclodextrin complex (E3-HPBCD) for the treatment of GSM.
View Article and Find Full Text PDFEfficacy and safety of an ultra-low-dose 0.005 % estriol vaginal gel in the prevention of urinary tract infections in postmenopausal women with genitourinary syndrome of menopause: A randomized double-blind placebo-controlled trial.
Maturitas
December 2024
Medical Department, ITF Research Pharma S.L.U., Madrid, Spain.
Article Synopsis
- This study tested an ultra-low-dose estriol vaginal gel (0.005%) to see if it could prevent urinary tract infections (UTIs) in postmenopausal women with genitourinary syndrome of menopause.
- The clinical trial involved 108 women who were divided into two groups: one received the estriol gel, while the other got a placebo gel, and they were monitored for 24 weeks.
- Results showed a 26% lower rate of UTIs in the group using estriol compared to placebo, indicating the gel is both safe and effective in reducing UTI occurrences and improving vaginal health.
Extended Chemical and Microbial Stability of Various Hormones in Phytobase and HRT Heavy Cream Bases.
Int J Pharm Compd
August 2024
Compounding Support Services, Fagron Academy, St. Paul, Minnesota, USA.
Article Synopsis
- The 2023 updates to USP chapter <800> and major revisions to USP <795> have made previous studies for extended beyond use dates (BUD) inadequate, prompting a need for new evidence in compounding.
- Researchers conducted stability indicating testing and antimicrobial effectiveness testing (AET) on 12 combinations of topical and transdermal hormone preparations using two cream vehicles, Phytobase™ and HRT Heavy™, resulting in a total of 24 tested formulas.
- The study evaluates the appropriateness of Phytobase™ and HRT Heavy™ for compounded hormone therapy (CHT) and examines their compatibility with various hormones like estriol, estradiol, testosterone, progesterone, and dehydroepiandroster
Treatment of Prepubertal Labial Adhesions with Topical Estriol + Testosterone: A Case Report.
Pediatr Rep
July 2024
Department of Woman Mother and Neonate, V. Buzzi Hospital, University of the Study of Milan, 20124 Milan, Italy.
Background: Labial adhesions, a frequent gynecological condition in prepubertal girls, occur when the labia minora adhere along the midline. The prevailing hypothesis about their etiology suggests that labial adhesion may occur when the delicate and non-estrogenized labia minora undergo an inflammatory response, triggered by exposure to an irritant environment. Therefore, conservative treatment involves the application of topical estrogen or betamethasone cream.
View Article and Find Full Text PDFFractional and Microablative CO LASER and Radiofrequency in the Treatment of Genitourinary Syndrome of Menopause: A Descriptive Study.
Photobiomodul Photomed Laser Surg
June 2024
Department of Gynecology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
This study aimed to evaluate the vagina clinically, cytologically, and histologically before and after treating genitourinary syndrome of menopause (GSM) with fractional microablative carbon dioxide LASER (COL), radiofrequency (RF), and estrogen vaginal cream (CT). Women with moderate-to-severe symptoms of GSM, denoted by a GSM Visual analog scale (VAS) score of >4, were eligible for this study. The patients were randomized into treatment groups.
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