AI Article Synopsis
- Researchers created silver nanoprism/silicon nanoparticle hybrid arrays for sensitive biomolecule detection using surface-enhanced Raman spectroscopy (SERS).
- The size and phosphorous doping of silicon nanoparticles significantly influenced the SERS enhancement quality, with the largest SiNPs providing the best results.
- The hybrid arrays demonstrated high stability, reproducibility, and even enabled DNA detection at a low concentration of 1.5 pg/µL, indicating their potential as a useful biosensing tool.
Article Abstract
In the present work, we have fabricated silver nanoprism (AgNPrs)/silicon nanoparticle (SiNPs) hybrid arrays for highly sensitive detection of biomolecules via surface-enhanced Raman spectroscopy (SERS) technique. SiNPs having 7 to 37 nm in size and with phosphorous doping varying from 1 × 10 to 1 × 10 cm were synthesized in nonthermal plasma synthesis. SiNPs were further immobilized on glass substrates using spin-coating, followed by deposition of AgNPrs using the drop-casting method. SERS studies showed that AgNPrs/SiNPs hybrid arrays exhibit substantial amplification of fingerprint bands of rhodamine 6G (R6G) compared to bare silicon as the reference. Raman signal intensity was found to be dependent on the size of SiNPs, with the largest nanoparticles exhibiting the highest SERS enhancement. In addition, an increase in phosphorous doping concentration was found to reduce R6G peak intensities. AgNPrs/SiNPs hybrid arrays showed excellent stability over time and high spot-to-spot reproducibility as well. Moreover, hybrid arrays enabled DNA detection through intense vibrational modes of human genomic DNA, with a lower detection limit of 1.5 pg/µL; indicating that AgNPrs/SiNPs sensors can serve as a reliable and cost-effective biosensing platform for rapid and label-free analysis of biomolecules.
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| http://dx.doi.org/10.1016/j.saa.2022.122262 | DOI Listing |
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