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http://dx.doi.org/10.1056/NEJMp2215556 | DOI Listing |
Appl Environ Microbiol
January 2025
Institute for Chemistry and Biology of the Marine Environment (ICBM), School of Mathematics and Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Vitamin B (cobalamin, herein B) is a key cofactor for most organisms being involved in essential metabolic processes. In microbial communities, B is often scarce, largely because only few prokaryotes can synthesize B and are thus considered B-prototrophs. B-auxotrophy is mostly manifested by the absence of the B-independent methionine synthase, MetE.
View Article and Find Full Text PDFSchmerz
January 2025
University Pain Center, University Hospital Carl Gustav Carus, Dresden, Germany.
In addition to the usual evaluation approach (usually a clinical randomized trial in the sense of the question: does an intervention work), complex interventions require further systematic investigations to prove their effectiveness. The role of the context in which the intervention is delivered is essential here, as is consideration of the question of why an intervention works (or does not work). Detailed recommendations exist for the planning and implementation of effectiveness studies on complex interventions, to which interdisciplinary multimodal pain therapy undoubtedly belongs.
View Article and Find Full Text PDFSchmerz
January 2025
UniversitätsSchmerzCentrum, Klinik für Anästhesiologie, Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Deutschland.
In addition to the usual evaluation approach (usually a clinical randomized trial in the sense of the question: does an intervention work), complex interventions require further systematic investigations to prove their effectiveness. The role of the context in which the intervention is delivered is essential here, as is consideration of the question of why an intervention works (or does not work). Detailed recommendations exist for the planning and implementation of effectiveness studies on complex interventions, to which interdisciplinary multimodal pain therapy undoubtedly belongs.
View Article and Find Full Text PDFJ Fam Psychol
January 2025
School of Psychological Science, University of Western Australia.
The construct of empowerment is associated with beneficial outcomes in numerous populations with well-being across multiple domains. Within families, empowerment has been found to be related to both parent and child well-being. As such, empowerment appears to be a promising concept to support parents of young (< 18 years) trans and gender diverse children and adolescents; however, what empowerment means for parents of trans children and adolescents is not known.
View Article and Find Full Text PDFJ Phys Ther Educ
January 2025
Beth P. Davis is the associate professor in the Department of Rehabilitation Medicine at the Emory University School of Medicine, 1441 Clifton Road NE, Suite 312, Atlanta, GA 30322 Please address all correspondence to Beth P. Davis.
Background And Purpose: Efforts focused on racial and ethnic diversity in Doctor of Physical Therapy (DPT) programs have been prioritized to increase enrollment of Underrepresented in Medicine (URiM) individuals. While increasing diversity is a positive step, this Program took strategic action to embed Diversity, Equity, and Inclusion (DEI)-informed principles into all program areas. This holistic approach catalyzed a cultural shift that reflects a deepened commitment to the society we serve.
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