Effect of extracts from several sponges of Yucatan Coast on and preliminary chemical investigation of the bioactive extract of () .

In this study, twenty-four organic extracts from six marine sponge species, collected at shallows of Yucatan, Mexico, were evaluated against trophozoites and Vero cells. The dichloromethane and hexane extracts of exhibited the highest antigiardiasic activity (IC = 1.00 and 2.11 µg/mL, respectively), as well as high selectivity (SI = 41.8 and > 47.4, respectively), while ethyl acetate and methanol extracts of , and methanol extract of showed moderate activity. Contrastingly, the extracts of and were considered non actives. Consequently, the dichloromethane extract of were subject to an exploratory chemical study, isolating cholesterol, two benzaldehyde derivatives, three benzoic acid derivatives, cytosine, and thymine.