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Differential diagnosis and comparison of diagnostic algorithms in children and adolescents with autoimmune encephalitis in Spain: a prospective cohort study and retrospective analysis.
Lancet Neurol
January 2025
Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer/CaixaResearch Institute, Hospital Clínic de Barcelona, Barcelona, Spain; Pediatric Neuroimmunology Unit, Neurology Department, Sant Joan de Déu Children's Hospital, Barcelona, Spain; Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain; European Reference Networks-RITA. Electronic address:
Background: The usefulness of current diagnostic approaches in children with suspected autoimmune encephalitis is unknown. We aimed to assess the diagnosis of autoimmune encephalitis in clinical practice and to compare the performance of two international diagnostic algorithms (one intended for patients of any age [general], the other intended for paediatric patients), with particular emphasis on the evaluation of patients with probable antibody-negative autoimmune encephalitis because this diagnosis suggests that immunotherapy should be continued or escalated but is difficult to establish.
Methods: We did a prospective cohort study that included all patients (<18 years of age) with suspected autoimmune encephalitis recruited at 40 hospitals in Spain whose physicians provided clinical information every 6 months for 2 years or more.
Validation of preterm birth related perinatal and neonatal data in the Canadian discharge abstract database to facilitate long-term outcomes research of individuals born preterm.
Int J Popul Data Sci
December 2024
Manitoba Centre for Health Policy, University of Manitoba, Winnipeg, Canada.
Introduction: The Canadian Institute of Health Information's (CIHI) Discharge Abstract Database (DAD) contains standardised administrative data on all hospitalisations in Canada, excluding Quebec.
Objectives: We aimed to validate preterm birth related perinatal and neonatal data in DAD by assessing its accuracy against the reference standard of the Canadian Neonatal Network (CNN) database.
Methods: We linked birth hospitalization data between the DAD and CNN databases for all neonates born <33 weeks gestational age (GA) admitted to the Neonatal Intensive Care Units in Winnipeg, Canada, between 2010 and 2022.
Use of mucolytics and inhaled antibiotics in the NICU.
J Perinatol
January 2025
Division of Neonatology, The Children's Regional Hospital at Cooper, Camden, NJ, USA.
Article Synopsis
- Clearance of airway secretions and treating respiratory infections are key challenges for caregivers in NICUs.
- Mucolytics help thin mucus for easier removal, but their effectiveness in neonates isn't well-studied compared to older children and adults.
- Though systemic antibiotics for respiratory infections can lead to side effects, inhaled options may target infected airways better, making it crucial to research their safety and effective dosage in premature and newborn infants.
Trends in Sickle Cell Disease Mortality: 1979-2020.
Pediatrics
December 2024
Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Background And Objectives: Although sickle cell disease (SCD)-related childhood mortality in the United States significantly improved in the 1990s, unclear is the trend in SCD-related mortality more recently given the continued disparities faced by this minoritized population. In this analysis, we aimed to (1) compare the overall and age-specific mortality rates from 1999 to 2009 vs 2010 to 2020 with a particular focus on the age of transition and (2) determine the most common causes of death for the US SCD population for 2010 to 2020.
Methods: We analyzed publicly available data from the Centers for Disease Control and Prevention WONDER database, a compilation of national-level mortality statistics from 1979 to 2020 derived from death certificates compiled by the National Center for Health Statistics.
Development of Personalised Immediate-Release Gel-Based Formulations Using Semi-Solid Extrusion.
Gels
October 2024
RAPSODEE, IMT Mines Albi, CNRS, University of Toulouse, 81013 Albi, France.
Precision in dosing is crucial for optimizing therapeutic outcomes and preventing overdosing, especially in preterm infants. Traditional manual adjustments to adapt the dose often lead to inaccuracies, contamination risks, and reduced precision. To overcome these challenges, semi-solid extrusion 3D printing was used to create personalised gel-based caffeine dosage forms.
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