Protection of skin cells from chronic infrared-A (IRA) irradiation is crucial for anti-photoaging of the skin. In this study, we investigated the protective activity of Rg3(S) and Rg3(S)-incorporated anionic soybean lecithin liposomes (Rg3/Lipo) with a size of approximately 150 nm against IRA-induced photodamage in human fibroblasts. The formulated Rg3/Lipo showed increased solubility in aqueous solution up to a concentration of 200 μg/ml, compared to free Rg3(S). In addition, Rg3/Lipo exhibited superior colloidal stability in aqueous solutions and biocompatibility for normal human dermal fibroblasts (NHDFs). After repeated IRA irradiation on NHDFs, elevated levels of cellular and mitochondrial reactive oxygen species (ROS) were greatly reduced by Rg3(S) and Rg3/Lipo. In addition, cells treated with Rg3/Lipo exhibited noticeably reduced apoptotic signals following IRA irradiation compared to untreated cells. Thus, considering aqueous solubility and cellular responses, Rg3/Lipo could serve as a promising infrared protector for healthy aging of skin cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9895989 | PMC |
| http://dx.doi.org/10.4014/jmb.2210.10048 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigating ultra-high dose rate water radiolysis using the Geant4-DNA toolkit and a Geant4 model of the Oriatron eRT6 electron linac.
Sci Rep
November 2024
Institute of Radiation Physics (IRA), Lausanne University Hospital and University of Lausanne, Lausanne, CH-1007, Switzerland.
Ultra-high dose rate FLASH radiotherapy, a promising cancer treatment approach, offers the potential to reduce healthy tissue damage during radiotherapy. As the mechanisms underlying this process remain unknown, several hypotheses have been proposed, including the altered production of radio-induced species under ultra-high dose rate (UHDR) conditions. This study explores realistic irradiation scenarios with various dose-per-pulse and investigates the role of pulse temporal structure.
View Article and Find Full Text PDFHighly-efficient recovery of silver from industrial cyanide-based plating effluent on TiO/activated carbon composites.
Chemosphere
November 2024
Department of Chemical Engineering, Faculty of Engineering, Mahidol University, Phuttamonthon 4 Road, Nakhon Pathom, 73170, Thailand; Advanced Microfabrication and Biomaterial for Organ-on-chip research unit (AMBiO), Faculty of Engineering, Mahidol University, Nakhon Pathom, 73170, Thailand; Associate Fellow of Royal Society of Thailand (AFRST), Bangkok, 10300, Thailand. Electronic address:
The release of silver-containing wastewater is an economic loss. In this works, the silver ions in the cyanide-based plating effluent of jewelry effluent was systematic recovered by the photocatalytic process using commercial semiconductors (TiO, ZnO, BiO and WO) and activated carbon (AC) enhanced semiconductors as the photocatalysts. The preliminary results demonstrated that the highest photocatalytic silver recovery was achieved via the use of TiO nanoparticles (NPs), ascribing to its better textural property that provided abundant active sites to undergo the reaction.
View Article and Find Full Text PDFInfrared-A to improve mood: an exploratory study of water-filtered infrared-A (wIRA) exposure.
Photochem Photobiol Sci
November 2024
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Diurnal preference to eveningness might predispose to depression. There is preliminary evidence of infrared-A (IR-A) induced whole-body hyperthermia (WBH) in the treatment of depression. In this exploratory study with 19 adults, we investigated the effects of a 20-min exposure of water-filtered IR-A (wIRA) to the skin of back and buttock area, without inducing WBH, on mood and assessed the outcome by diurnal preference (#R19047, approval on 7 May 2019).
View Article and Find Full Text PDFReview of chemical models and applications in Geant4-DNA: Report from the ESA BioRad III Project.
Med Phys
September 2024
Univ. Bordeaux, CNRS, LP2I, UMR 5797, Gradignan, France.
Article Synopsis
- * This module has been enhanced over time to boost performance and allow for more detailed simulations in bulk solutions, contributing to understanding early DNA damage and comparing with real experimental data.
- * The latest advancements and various applications of this module are discussed in the context of the ESA BioRad III Project, showcasing its utility in modeling chemical processes.
METhodological RadiomICs Score (METRICS): a quality scoring tool for radiomics research endorsed by EuSoMII.
Insights Imaging
January 2024
Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy.
Purpose: To propose a new quality scoring tool, METhodological RadiomICs Score (METRICS), to assess and improve research quality of radiomics studies.
Methods: We conducted an online modified Delphi study with a group of international experts. It was performed in three consecutive stages: Stage#1, item preparation; Stage#2, panel discussion among EuSoMII Auditing Group members to identify the items to be voted; and Stage#3, four rounds of the modified Delphi exercise by panelists to determine the items eligible for the METRICS and their weights.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!