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In June 2020, 32,000 people began HIV Pre-exposure prohylaxis (PrEP) in France. The objective of this work is to propose PrEP for migrants in city medical offices in collaboration with hospitals. This is happening in the Goutte d’Or neighborhood of Paris where one-third of the inhabitants were born abroad [1]. The Goutte d’Or multidisciplinary and multi-site health center (MSP), composed of independent health professionals, hosted this study.The obstacles to overcome are multifold, notably talking about sexuality and presenting a prevention method that is little known to people in migratory situations. In addition, the first prescription of ARVs in this period had to be given by a hospital doctor (until June 1st 2021) [2].The working hypothesis is that general practitioners can overcome these obstacles within the framework of a protocol defining the discussions on sexuality and the organization of a PrEP consultation along with the GP and a hospital doctor within the city doctor’s office.The study took place between March 1st 2018 and October 31st 2020. 180 questionnaires concerning opportunities for PrEP were distributed by general practitioners (GP) and a midwife from the MSP. 43 people were identified as qualifying for the PrEP. 24 PrEP were prescribed, 23 continuously, and one on demand. A semi-directive interview on sexual health was proposed to the 43 people identified for PrEP consultations.The in-depth interviews confirmed that although sexual health may not be the primary interest of the consultants, there are nevertheless real needs that are not often taken into account.