AI Article Synopsis
- - The study focused on Japanese patients with acute myeloid leukemia (AML) specifically looking at those with unusual cup-like nuclei, finding that about 23% of AML cases studied had this unique feature.
- - All identified cases of cup-like AML were linked to FLT3-ITD mutations and showed a high occurrence of complications like disseminated intravascular coagulation and acute cerebral infarction.
- - The findings suggest that AML with cup-like nuclei may be more prevalent than previously thought, indicating the need for healthcare professionals to recognize and understand this specific morphology.
Article Abstract
In this study, we examined a cohort of Japanese patients with acute myeloid leukemia (AML) with cup-like nuclei. In particular, we attempted to provide a detailed definition of the clinical features of AML with cup-like nuclei. The clinical records of patients diagnosed with de novo AML were collected retrospectively. We showed that approximately 23% of all patients with AML diagnosed during the study period had AML with cup-like nuclei. All three cup-like AML cases had FLT3-ITD mutations. In addition, we reported a high incidence of disseminated intravascular coagulation and acute cerebral infarction in patients with AML with cup-like nuclei. Our results show that AML with cup-like nuclei may be more common than expected. Due to these unique characteristics, recognition of this morphology is recommended.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898714 | PMC |
| http://dx.doi.org/10.3960/jslrt.22020 | DOI Listing |
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Article Synopsis
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