A series of novel 2‑fluoro ketolide antibiotics with 11,12‑quinoylalkyl side chains derived from telithromycin and cethromycin were designed and synthesized. The corresponding targets 2a-o were tested for their in vitro activities against a series of macrolide-sensitive and macrolide-resistant pathogens. Some of them showed a similar antibacterial spectrum and comparable or slightly better activity to telithromycin. Among them, compounds 2g and 2k, displayed excellent activities against macrolide-sensitive and macrolide-resistant pathogens.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2022.129115 | DOI Listing |
Publication Analysis
Top Keywords
novel 2‑fluoro
8
2‑fluoro ketolide
8
ketolide antibiotics
8
antibiotics 1112‑quinoylalkyl
8
1112‑quinoylalkyl side
8
side chains
8
macrolide-sensitive macrolide-resistant
8
macrolide-resistant pathogens
8
synthesis antibacterial
4
antibacterial activity
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!