Ethnopharmacological Relevance: Caesalpinia coriaria (Jacq.) Willd is widely used as a traditional medinal plant in Mexico for protective and healing purposes and the treatment of gastrointestinal diseases.
Aim Of The Study: To investigate the gastroprotective effect of extract of Caesalpinia coriaria pods against ethanol-induced and indomethacin-induced gastric lesion models, its anti-inflammatory and antioxidative activities, and its main compounds through LC-MS analysis.
Materials And Methods: Male Wistar rats were orally administered a methanol extract obtained from the pods of C. coriaria at doses of 10, 30, 100, and 300 mg/kg prior to inducing gastric lesions with ethanol or indomethacin. Gastric mucosal lesions were evaluated by macroscopic and histopathological alterations. Determination of prostaglandin E (PGE), alpha tumor necrosis factor (TNF-α), leukotriene B (LTB), nitrites/nitrates, superoxide dismutase (SOD), and HS gastric levels were investigated. Its main compounds of the active extract through LC-MS analysis.
Results: Phenolic compounds were identified as major components of methanol extract. LC-MS analysis identified 15 constituents, and the significant compounds were gallic acid, 3-O-galloylquinic acid, digalloylglucose, tetragalloylglucose, valoneic acid dilactone, pentagalloylglucose, digalloylshikimic acid, and ellagic acid. Pretreatment with the extract at doses of 100 and 300 mg/kg significantly reduced gastric ulcer lesions in both models. Compared with the reference drugs (omeprazole or ranitidine, respectively), no significant difference was found (p < 0.05). The extract's gastroprotective effect was accompanied by significant decreases in leukocyte recruitment, and gastric levels of TNF-α and LTB by two to fourfold (p < 0.05). Also, gastric levels of PGE gastric levels were maintained and the antioxidant enzyme activities of SOD and nitrate/nitrite in the gastric tissue were improved (p < 0.05). The LC-MS analysis indicated the presence of hydrolyzable tannins (mainly gallic acid derivatives).
Conclusion: The results suggest that the gastroprotective effect of the methanol extract of C. coriaria pods occurs through anti-inflammatory, antioxidant, and NO modulation properties, and gallic acid derivatives may be the main possible compounds responsible for its actions.
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http://dx.doi.org/10.1016/j.jep.2022.116057 | DOI Listing |
Nat Prod Res
January 2025
Department of Botany, D.B.S. (PG) College, Dehradun, Uttarakhand, India.
The aim of the present study was to demonstrate the phytochemical characterisation, antioxidant and antimicrobial properties of methanol extracts of leaf parts of . The Phytochemical characterisation by GC-MS analysis revealed the presence of 30 phytoconstituents such as Methyl commate A (14.69%), Phytol (13.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
To illustrate the anti-diabetic properties of Berberis orthobotrys seeds was the aim of the current study. After a series of experiments, two doses of aqueous methanolic extract of the seeds were selected i.e.
View Article and Find Full Text PDFDrug Dev Ind Pharm
January 2025
Laboratory of Virology and Cellular Technology, Department of Chemistry, Biotechnology, and Bioprocess Engineering, Universidade Federal de São João del-Rei, Ouro Branco, MG, Brazil.
Background: , a notable plant species, has garnered interest for its medicinal properties, including anti-inflammatory, antibacterial and antiviral effects. A vaccine for Chikungunia virus is still under evaluation and no specific antiviral drug has been licensed to date.
Objective: The work investigated antiviral activity of ethyl acetate (EAEF) and methanolic (EMF) extracts from leaves in mammalian cells exposed to (CHIKV).
Chem Biodivers
January 2025
Department of Agricultural Chemistry & Biochemistry, The University of Agriculture, Peshawar, Pakistan.
The medicinal value of plants depends on minerals and nutrients and their complexation with chemotherapeutic compounds. The present study aimed to evaluate the phytochemical composition with anti-inflammatory and antidiarrheal potential of Heliotropium rariflorum. Among nutrients, fibers were maximum (25.
View Article and Find Full Text PDFAnal Bioanal Chem
January 2025
Doping Control Laboratory, Department of Diagnostic Sciences, Ghent University, Block B, Ottergemsesteenweg 460, BE-9000, Ghent, Belgium.
Dried urine spots have recently been proposed as an alternative matrix in the anti-doping field. Drying urine may open the opportunity to limit microbial and thermal degradation of the prohibited substances during transportation to the anti-doping laboratories without the need for refrigeration or freezing. In this study, a multi-targeted initial testing procedure was developed for the determination of 237 prohibited drugs/metabolites from 11 different classes in dried urine spots.
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