AI Article Synopsis
- Idiopathic nodular glomerulosclerosis is a serious kidney condition often leading to poor outcomes, marked by specific lesions in the kidneys and occurring without diabetes.
- A case study of a 69-year-old woman with no relevant medical history revealed this condition after she experienced kidney dysfunction and protein levels in urine.
- Treatment with esaxerenone, combined with current medication, significantly improved her symptoms and preserved kidney function for over a year, indicating that targeted therapy could be beneficial for this disorder.
Article Abstract
Idiopathic nodular glomerulosclerosis has a poor renal prognosis and is characterized by diffuse nodular glomerulosclerotic lesions in the absence of diabetic mellitus. Here, we report the case of a 69-year-old woman with no smoking history who developed renal dysfunction and proteinuria in the absence of overt diabetes or obesity. A biopsy specimen showed nodular mesangial sclerosis with arteriolar hyalinosis and severe large-vessel arteriosclerosis, leading to a diagnosis of idiopathic nodular glomerulosclerosis. Addition of esaxerenone to her existing renin-angiotensin-aldosterone inhibitor therapy led to a rapid decrease in the proteinuria levels and the maintenance of renal function without any complications for more than a year. The results suggest that intensive renin-angiotensin-aldosterone blockade might be an effective treatment for idiopathic nodular glomerulosclerosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393922 | PMC |
| http://dx.doi.org/10.1007/s13730-022-00766-3 | DOI Listing |
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