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Invasive Management of Hypertrophic Cardiomyopathy With Clinically Important Obstruction: Catheter Intervention Is Superior.
Can J Cardiol
May 2024
Liverpool Heart and Chest Hospital, Liverpool, United Kingdom. Electronic address:
Hypertrophic cardiomyopathy is a common inherited cardiac condition where the myocardium progressively thickens in the absence of abnormal loading conditions. Left ventricular hypertrophy often leads to outflow tract obstruction, and this confers significant mortality and morbidity implications. Septal reduction therapies aim to relieve the obstruction in an attempt to reduce the burden of symptoms and potentially improve prognosis.
View Article and Find Full Text PDFPoint-Counterpoint: Transfer function analysis of dynamic cerebral autoregulation: To band or not to band?
J Cereb Blood Flow Metab
September 2023
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA.
Transfer function analysis (TFA) of dynamic cerebral autoregulation (dCA) is based on linear system theory to examine the relationship between changes in blood pressure and cerebral blood flow. With TFA, dCA is characterized as a frequency-dependent phenomenon quantified by gain, phase, and coherence in the distinctive frequency bands. These frequency bands likely reflect the underlying regulatory mechanisms of the cerebral vasculature.
View Article and Find Full Text PDFPoint/counterpoint: Arterial blood pressure response to exercise does relate to exercise-induced improvement in cognitive function.
J Cereb Blood Flow Metab
April 2023
Department of Biomedical Engineering, Toyo University, Kawagoe, Saitama, Japan.
Exercise is a beneficial intervention to prevent cognitive dysfunction. However, an optimal exercise prescription for preventing dementia has not been established because the physiological mechanism(s) of exercise-induced improvements in cognitive function remains unclear. Interestingly, our recent study demonstrated that individuals with a higher exercise pressor response exhibit less exercise-induced cognitive improvement, suggesting that individual differences in cardiovascular responses to exercise or its associated physiological factors, may be related to exercise-induced alterations in cognitive function.
View Article and Find Full Text PDFPoint/counterpoint: Arterial blood pressure response to exercise does not relate to exercise-induced improvement in cognitive function.
J Cereb Blood Flow Metab
April 2023
Dept. of Exercise and Sport Science, University of New England, Armidale, Australia.
Acute exercise has been shown to transiently improve specific aspects of cognitive function, however the mechanism governing these effects remain unclear. Blood pressure responses during exercise have been hypothesized to be a primary contributing factor, in part through its influence on cerebral blood flow. In this counterpoint, we highlight the inconsistent and weak associations between changes in blood pressure, cerebral blood flow and cognitive responses during and following acute exercise.
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