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Nanoparticle-mediated Klotho gene therapy prevents acute kidney injury to chronic kidney disease transition through regulating PPARα signaling in renal tubular epithelial cells.
Biomaterials
April 2025
Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China; NHC Key Laboratory of Clinical Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, 510080, China; Department of Nephrology, Jieyang People's Hospital, Jieyang, 522000, China. Electronic address:
Klotho is an anti-aging protein produced primarily by tubular epithelial cells (TECs). Down-regulated expression of Klotho in injured TECs plays a key pathogenic role in promoting acute kidney injury (AKI) to chronic kidney disease (CKD) transition, yet therapeutic approaches targeting the restoration of renal Klotho levels remain challenging for clinical application. Here, we synthesize polydopamine-polyethylenimine-l-serine-Klotho plasmid nanoparticles (PPSK NPs), which can safely and selectively deliver the Klotho gene to the injured TECs through binding kidney injury molecule-1 and maintain the expression of Klotho protein.
View Article and Find Full Text PDFThe Role of Natriuretic Peptides in the Management of Heart Failure with a Focus on the Patient with Diabetes.
J Clin Med
October 2024
Department of Medicine and Surgery, University of Milano Bicocca, 20126 Milan, Italy.
Natriuretic peptides (NPs) are polypeptide hormones involved in the homeostasis of the cardiovascular system. They are produced by cardiomyocytes and regulate circulating blood volume and sodium concentration. Clinically, measurements of brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) are recommended by international guidelines as evidence is accumulating on their usefulness.
View Article and Find Full Text PDFEvaluation of nurse practitioners' extended scope of practice in a regional hospital emergency department in tropical Australia.
Aust J Rural Health
December 2024
Department of Emergency Medicine, Cairns Hospital, Cairns, Queensland, Australia.
Objectives: There is very little literature examining the workload and impact of nurse practitioners (NPs) working in emergency departments (ED) in regional and rural Australia. The aim of this paper was to review the ED NPs scope of practice in the ED discharge stream and patient outcomes at Cairns Hospital over a 7-month period.
Methods: This retrospective study examined the ED electronic medical record between 14 May 2019 and 31 December 2019.
Identification of the Vulnerability of Atherosclerotic Plaques by a Photoacoustic/Ultrasonic Dual-Modal cRGD Nanomolecular Probe.
Int J Nanomedicine
September 2024
Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, Wuhan, 430060, People's Republic of China.
Objective: To explore the feasibility of using cRGD-GNR-PFP-NPs to assess plaque vulnerability in an atherosclerotic plaque mouse model by dual-modal photoacoustic/ultrasonic imaging.
Methods: A nanomolecular probe containing gold nanorods (GNRs) and perfluoropentane (PFP) coated with the cyclic Arg-Gly-Asp (cRGD) peptide were prepared by double emulsion solvent evaporation and carbodiimide methods. The morphology, particle size, potential, cRGD conjugation and absorption features of the nanomolecular probe were characterized, along with its in vitro phase transformation and photoacoustic/ultrasonic dual-modal imaging properties.
Nano-scale characterization of iron-carbohydrate complexes by cryogenic scanning transmission electron microscopy: Building the bridge to biorelevant characterization.
Heliyon
September 2024
CSL Vifor, Flughofstrasse 61, CH-8152, Glattbrugg, Switzerland.
Article Synopsis
- Iron deficiency and anemia are major global health issues, and intravenous iron carbohydrate nanoparticles are vital for effective treatment.
- Our study used advanced cryogenic Scanning Transmission Electron Microscopy (cryo-STEM) to analyze the physical structure of these nanoparticles, revealing they typically have iron cores about 2 nm in size and distinct cluster-like shapes in various products.
- By employing this sophisticated imaging technique, we not only preserved the specimens' structural integrity but also contributed insights that could enhance understanding of how these nanoparticles function, including the development of a machine learning tool for better image analysis.
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