AI Article Synopsis
- Organism survival hinges on the effective delivery and use of oxygen, particularly vital for brain health after injuries.
- Secondary brain damage can arise from issues like impaired metabolism and oxygen level disturbances (hypoxia and hyperoxia).
- Recent findings emphasize the significance of clinical protocols in improving oxygen delivery, which can lower mortality rates in brain-injured patients by addressing both supply and demand for oxygen.
Article Abstract
Organism survival depends on oxygen delivery and utilization to maintain the balance of energy and toxic oxidants production. This regulation is crucial to the brain, especially after acute injuries. Secondary insults after brain damage may include impaired cerebral metabolism, ischemia, intracranial hypertension and oxygen concentration disturbances such as hypoxia or hyperoxia. Recent data highlight the important role of clinical protocols in improving oxygen delivery and resulting in lower mortality in brain-injured patients. Clinical protocols guide the rules for oxygen supplementation based on physiological processes such as elevation of oxygen supply (by mean arterial pressure (MAP) and intracranial pressure (ICP) modulation, cerebral vasoreactivity, oxygen capacity) and reduction of oxygen demand (by pharmacological sedation and coma or hypothermia). The aim of this review is to discuss oxygen metabolism in the brain under different conditions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698645 | PMC |
| http://dx.doi.org/10.3390/jpm12111763 | DOI Listing |
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