AI Article Synopsis
- Menopause marks the end of reproductive life and is linked to health issues like heart disease, osteoporosis, and breast cancer.
- Genetic factors play a significant role in determining the age at which menopause occurs, influenced by multiple genes instead of just one.
- Recent advances in genomic technology have led to large-scale studies that identify DNA repair system defects as a key genetic factor, prompting the need for more diverse research to better understand menopause and associated diseases across different populations.
Article Abstract
Menopause is not only the end of reproductive life, it is also related to diseases such as hyperlipidaemia, atherosclerotic cardiovascular disease, osteoporosis and breast cancer. Traditional epidemiological studies have found that heredity is the main determinant of age at natural menopause (ANM). Early studies on genetic factors were limited to candidate gene studies. Menopause age is not inherited by a single gene, but is the result of multiple gene effects. With the development of genomic technology, the Reproductive Genetics Consortium conducted several genome-wide association studies on ANM in people of European descent, and found that defects in DNA damage repair pathways were the main genetic mechanism. In recent years, due to the ethnic heterogeneity of ANM, there has been further development of global studies into multi-ethnic and trans-ethnic genome-wide association studies. Further genetic and epidemiological studies, including polygenetic score and genetic mechanism research, should be conducted to investigate the pathogenesis and mechanism with respect to menopause and its related diseases.
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| http://dx.doi.org/10.1016/j.rbmo.2022.11.017 | DOI Listing |
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