AI Article Synopsis
- The study examined the brains of 18-day old fetuses and neonate rats at different ages (15, 30, and 100 days) that developed in space, specifically on the Cosmos-1514 mission.
- No major structural changes were noted in the brain of the fetuses or pups, suggesting overall brain integrity was maintained.
- However, 18-day fetuses showed signs of low tissue oxygenation and delays in important processes like cell migration and differentiation, but these issues normalized once embryos returned to Earth’s gravity.
Article Abstract
Macroscopic and light microscopic examinations of the brain of 18-day fetuses, and neonate 15-, 30- and 100- day rats whose embryonic development from day 13 to day 18 occurred in space flight on Cosmos-1514 did not reveal any changes in the brain structures of the fetuses or pups of the three ages. However, the brain of the 18-day fetuses that developed in flight showed signs of insufficient tissue oxygenation, trends toward delayed cell migration in the cortex and delayed differentiation of neurosecretory cells of the hypothalamic supraoptic nuclei. The cell differentiation rate returned to normal during continued embryogenesis after flight at 1 g.
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