Luminescent polyelectrolytes with antiviral activity.

Russ Chem Bull

Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bol'shoy prosp. V. O., 199004 St. Petersburg, Russian Federation.

Published: December 2022

Radical polymerization was used to synthesize and characterize (co)polymers with sodium styrenesulfonate (NaSS), 4-methacryloylamidosalicylic acid (MASA), and -vinylpyrrolidone, which have a low cytotoxicity and a high antiviral activity against the human respiratory syncytial virus. The interaction of copolymers with Tb ions was studied. The complexes formed in dilute aqueous solutions at a concentration of MASA units ⩽ 1 · 10 mol L demonstrate a strong luminescence. The luminescence intensity is independent of copolymer composition, but increases when the NaSS units are substituted with uncharged N-vinylpyrrolidone units. The obtained Tb polymer complexes are promising luminescent sensors for the visualization of biological objects interacting with copolymers.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762657PMC
http://dx.doi.org/10.1007/s11172-022-3662-4DOI Listing

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