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Function: file_get_contents
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Function: simplexml_load_file_from_url
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Function: pubMedSearch_Global
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Function: require_once
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File: /var/www/html/application/controllers/Detail.php
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Function: pubMedGetRelatedKeyword
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Objective: To report a unique case of total fertilization failure (TFF) after in vitro fertilization with intracytoplasmic sperm injection related to homozygous gene mutation and summarize the current literature and management of TFF.
Design: Case report.
Setting: Academic fertility center.
Patients: A 25-year-old woman and her 35-year-old partner with a history of near-complete fertilization failure after 2 cycles of in vitro fertilization/intracytoplasmic sperm injection.
Interventions: Consultation with medical and commercial genetic testing for , , and .
Main Outcome Measures: Oocyte fertilization.
Results: The patient was homozygous for pathogenic variant impacting oocyte activation and resulting in infertility.
Conclusions: In the setting of TFF, early consideration should be given to genetic testing to assist couples in clinical decision-making and help limit the financial and emotional burden associated with unsuccessful fertility intervention.
Download full-text PDF |
Source |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783144 | PMC |
http://dx.doi.org/10.1016/j.xfre.2022.08.007 | DOI Listing |
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