AI Article Synopsis
- - The study aimed to compare clinical and paraclinical similarities between trauma patients who tested positive (PCR+ve) for COVID-19 and those who tested negative (PCR-ve) using a case-control format.
- - Results showed that while the PCR+ve group exhibited lower lymphocyte counts, CPK, and CRP levels, these differences were not significant when analyzed further, and both groups shared similar clinical findings and comorbidities.
- - The PCR+ve group had a higher risk of mortality (OR=2.88), indicating they are more likely to experience severe outcomes, leading researchers to suggest a larger study should be conducted to better understand these differences.
Article Abstract
Objective: To compare clinical and paraclinical similarities between trauma patients with positive RT-PCR tests (PCR+ve) and the RT-PCR negative ones (PCR -ve).
Methods: This a case-control study, where cases had a PCR+ve and controls had a negative result. Two groups were compared regarding (para) clinical values. Multivariable binary logistic regression analysis investigated the variables predicting COVID-19 and the mortality rate.
Results: Both groups were similar regarding the clinical findings and comorbidities (>0.05). PCR+ve group had lower lymphocyte count (1.41 [1.45] vs. 1.66 [1.61], =0.030), CPK level (411 [928.75] vs. 778 [1946.5]. =0.006) and CRP level (17 [42.5] vs. 24 [50.75], =0.004). However, none of these findings were significant in the multivariable analysis. Finally, PCR+ve group had increased odds of death (OR=2.88; 95% CI=1.22-7.41).
Conclusion: Unlike our primary hypothesis, the study failed to mark any significant (para) clinical features guiding us to detect COVID-19 earlier in trauma patients. Moreover, the PCR+ve group is at increased mortality risk. A larger, multicentric prospective study should be designed to address this issue.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758711 | PMC |
| http://dx.doi.org/10.30476/BEAT.2022.96357.1387 | DOI Listing |
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