Pharmaceutical is one of the noteworthy classes of emerging contaminants. These biologically active compounds pose a range of deleterious impacts on human health and the environment. This is attributed to their refractory behavior, poor biodegradability, and pseudopersistent nature. Their large-scale production by pharmaceutical industries and subsequent widespread utilization in hospitals, community health centers, and veterinary facilities, among others, have significantly increased the occurrence of pharmaceutical residues in various environmental compartments. Several technologies are currently being evaluated to eliminate pharmaceutical compounds (PCs) from aqueous environments. Among them, adsorption appears as the most viable treatment option because of its operational simplicity and low cost. Intensive research and development efforts are, therefore, currently underway to develop inexpensive adsorbents for the effective abatement of PCs. Although numerous adsorbents have been investigated for the removal of PCs in recent years, biochar-based adsorbents have garnered tremendous scientific attention to eliminate PCs from aqueous matrices because of their decent specific surface area, tunable surface chemistry, scalable production, and environmentally benign nature. This review, therefore, attempts to provide an overview of the latest progress in the application of biochar for the removal of PCs from wastewater. Additionally, the fundamental knowledge gaps in the domain knowledge are identified and novel strategic research guidelines are laid out to make further advances in this promising approach towards sustainable development.
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http://dx.doi.org/10.1007/s42768-022-00118-y | DOI Listing |
Front Biosci (Elite Ed)
November 2024
Food Science Department, Agriculture College, Basrah University, 61001 Basrah, Iraq.
Background: Flavonoids are among the most important compounds found in plants, since laboratory studies have shown them to be a daily requirement in human diets due to their various health benefits. Therefore, this study focused on extracting, purifying, and measuring the antioxidant activity of the flavonoid quercetin, which is widely found in plants and possesses a variety of biological activities, from different plant sources.
Methods: The extraction of quercetin was performed using several methods (chemical, physical, and enzymatic) and several extraction solutions (water, ethanol, and chloroform) from several plants (spinach, dill, Onion Skin, , sumac, digalkhasab chemri, and leelwi chemri).
JACS Au
December 2024
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
High-throughput screening (HTS) is a crucial technique for identifying potential hits to fuel drug discovery pipelines. However, this process naturally concentrates nuisance compounds that are not optimizable yet signal positively in a convincing manner. To be able to understand what types of nuisance compounds a particular assay is sensitive to, would be of great utility in being able to prioritize progressable over nonprogressable screening hits.
View Article and Find Full Text PDFJACS Au
December 2024
State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, No. 345 Lingling Road, Shanghai 200032, China.
Macrocyclization is a compelling strategy for conventional drug design for improving biological activity, target specificity, and metabolic stability, but it was rarely applied to the design of PROTACs possibly due to the mechanism and structural complexity. Herein, we report the rational design of the first series of "Head-to-Tail" macrocyclic PROTACs. The resulting molecule exhibited pronounced Brd4 protein degradation with low nM DC values while almost totally dismissing the "hook effect", which is a general character and common concern of a PROTAC, in multiple cancer cell lines.
View Article and Find Full Text PDFOncol Res
December 2024
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC.
View Article and Find Full Text PDFDrug Des Devel Ther
December 2024
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, People's Republic of China.
Purpose: Diabetes mellitus-induced erectile dysfunction (DMED) lacks targeted therapies. This study investigates the mechanisms and targets of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules (RAG) in treating DMED using network pharmacology and animal models.
Methods: We identified RAG's active ingredients and potential targets from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.
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