AI Article Synopsis
- Colorectal cancer (CRC) is the third most common cancer globally and often spreads to the liver, which is a primary site for metastasis due to its blood supply from the intestinal system.
- The process of CRC cells spreading to the liver involves several steps, including the persistence of the original tumors, invading blood vessels, and establishing new growths in the liver.
- The review addresses how CRC cells gain stem-like properties, interact with liver and immune cells, evaluates current immunotherapy strategies and their challenges, and looks toward future therapies based on advanced sequencing technologies.
Article Abstract
Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related mortality worldwide. A total of 20% of CRC patients present with distant metastasis. The hepatic portal venous system, responsible for collecting most intestinal blood, makes the liver the most common site of CRC metastasis. The formation of liver metastases from colorectal cancer is a long and complex process. It involves the maintenance of primary tumors, vasculature invasion, distant colonization, and metastasis formation. In this review, we serve on how the CRC cells acquire stemness, invade the vascular, and colonize the liver. In addition, we highlight how the resident cells of the liver and immune cells interact with CRC cells. We also discuss the current immunotherapy approaches and challenges we face, and finally, we look forward to finding new therapeutic targets based on novel sequencing technologies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9772455 | PMC |
| http://dx.doi.org/10.3389/fendo.2022.1081585 | DOI Listing |
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