While split-thickness autologous skin grafts remain the most common method of definitive burn wound closure, dermal substitutes have emerged as an attractive option. There are many advantages of utilizing a dermal substitute, notably reducing the need for donor tissue and subsequent iatrogenic creation of a secondary wound. However, there are disadvantages with each that most be weighed and factored into the decision. And most come at a high initial financial cost. There is little comparative literature of the various available and emerging products. This analysis was performed to objectively present risks and benefits of each option.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10185112 | PMC |
| http://dx.doi.org/10.1093/jbcr/irac131 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preparation and Rheological Evaluation of Thiol-Maleimide/Thiol-Thiol Double Self-Crosslinking Hyaluronic Acid-Based Hydrogels as Dermal Fillers for Aesthetic Medicine.
Gels
November 2024
School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
This study presents the development of thiol-maleimide/thiol-thiol double self-crosslinking hyaluronic acid-based (HA) hydrogels for use as dermal fillers. Hyaluronic acid with varying degrees of maleimide substitution (10%, 20%, and 30%) was synthesized and characterized, and HA hydrogels were fabricated using two molecular weights of four-arm polyethylene glycol (PEG10K/20K)-thiol as crosslinkers. The six resulting HA hydrogels demonstrated solid-like behavior with distinct physical and rheological properties.
View Article and Find Full Text PDFIndications for the use of dermal substitutes in patients with acute burns and in reconstructive surgery after burns: A systematic review.
Wound Repair Regen
December 2024
Alliance of Dutch Burn Care (ADBC), Burn Centre, Red Cross Hospital, Beverwijk, The Netherlands.
Deep dermal and full-thickness burns often result in scar sequelae such as contractures, hypertrophy, pain and itching following split-thickness skin grafting. Dermal substitutes are currently employed alongside split-thickness skin grafting to enhance clinical outcomes, though their indications remain a subject of ongoing debate. This systematic review aims to clarify the indications for the application of dermal substitutes in burn patients, in both acute and reconstructive settings.
View Article and Find Full Text PDFThe Efficacy of Biodegradable Temporising Matrix for Upper Limb Reconstruction: A Systematic Review and Meta-Analysis.
Cureus
December 2024
Plastic Surgery, Nottingham University Hospitals NHS Trust, Nottingham, GBR.
The objective of this systematic review and meta-analysis is to assess the efficacy of the biodegradable temporising matrix (BTM) (NovoSorb; PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia) in the reconstruction of complex upper extremity wounds. The authors conducted a systematic review and meta-analysis as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines assessing the efficacy of BTM in complex upper extremity wound reconstruction. The primary outcome measures were successful BTM integration and the proportion of wounds healed.
View Article and Find Full Text PDFA Randomized Controlled Clinical Trial Comparing the Use of High Purity Type-I Collagen-Based Skin Substitute vs. Dehydrated Human Amnion/Chorion Membrane in the Treatment of Diabetic Foot Ulcers.
Cureus
December 2024
Plastic Reconstructive and Aesthetic Surgery, Adichunchanagiri Institute of Medical Sciences, B. G. Nagara, IND.
Article Synopsis
- - Diabetic foot ulcers (DFUs) are a significant and expensive issue for diabetes patients, leading to increased healthcare costs and morbidity.
- - A study compared two treatments for DFUs: a high-purity type-I collagen skin substitute (HPTC) and dehydrated human amnion/chorion membrane (dHACM) over four weeks, with 28 patients participating.
- - Results showed that HPTC led to better healing outcomes, with 85.71% of patients achieving at least 50% wound size reduction compared to 50% for dHACM, suggesting HPTC may be a more effective treatment for chronic DFUs.
A Novel Approach to Aplasia Cutis Congenita With PolyNovo BTM.
J Craniofac Surg
December 2024
Department of Plastic and Reconstructive Surgery, Monash Health, Melbourne, VIC, Australia.
Aplasia cutis congenita (ACC) is a rare congenital condition characterized by the absence of skin and subcutaneous tissue, typically affecting the scalp. This case report presents a female infant born at 38+3 weeks with a posterior midline scalp defect measuring 15×12.5 mm, involving skin, subcutaneous tissue, and calvarium.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!