AI Article Synopsis
- Patients with Sheehan syndrome (SS) are at higher risk for coronary artery disease (CAD) due to factors like obesity, high cholesterol, and chronic inflammation, prompting the study to analyze various cardiovascular risk markers.
- In a case-control study involving 63 SS patients and 65 matched controls, results showed significantly elevated levels of inflammatory markers (hsCRP, ApoB, Lp(a)) in SS patients compared to controls, along with a higher prevalence of coronary artery calcium (CAC).
- The findings indicate that although most SS patients were classified as low risk according to the Framingham risk score, a significant portion had a high CAC score, suggesting they are at elevated risk for CAD despite being asymptomatic.
Article Abstract
Objective: Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lipoprotein A [Lp(a)], this study applies Framingham risk score (FRS) and coronary artery calcium (CAC) score to compute a 10-year probability of cardiovascular (CV) events in SS patients.
Design: Case-control study Sixty-three SS patients, on a stable hormonal replacement treatment except for growth hormone and 65 age, body mass index and parity-matched controls.
Measurements: Measurement of serum hsCRP, ApoB and Lp(a) and estimation of CAC with 16-row multislice computed tomography scanner.
Results: The concentrations of hsCRP, ApoB and Lp(a) were significantly higher in SS patients than in controls (p < .01). After calculating FRS, 95.2% of SS patients were classified as low risk, 4.8% as intermediate risk and all controls were classified as low risk for probable CV events. CAC was detected in 50.7% SS patients and 7.6% controls (p = .006). According to the CAC score, 26.9% SS patients were classified as at risk (CAC > 10) for incident CV events as against 1.6% controls. The mean Multi-Ethnic Study of Atherosclerosis (MESA) score was significantly higher in patients with SS than controls. CAC corelated significantly with fasting blood glucose (r = .316), ApoB (r = .549), LP(a) (r = .310) and FRS (r = .294).
Conclusion: Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD.
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| http://dx.doi.org/10.1111/cen.14871 | DOI Listing |
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