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Research and application of intelligent diagnosis and treatment engineering bacteria.
Front Bioeng Biotechnol
December 2024
Department of Gynecology, Peking University First Hospital Ningxia Women and Children's Hospital, Yinchuan, Ningxia, China.
For over a century, scientists have been harnessing the therapeutic potential of bacteria in treating diseases. The advent of synthetic biology in recent years has propelled the development of genetically engineered bacteria with enhanced intelligence. These bacteria can autonomously detect environmental cues and relay them to pivotal promoters, leading to the expression of functional proteins.
View Article and Find Full Text PDFChemoenzymatic C,C-Bond Forming Cascades by Cryptic Vanadium Haloperoxidase Catalyzed Bromination.
Org Lett
December 2024
Biomimetic Catalysis, Catalysis Research Center, TUM School of Natural Sciences, Technical University of Munich, Lichtenbergstrasse 4, 85748 Garching, Germany.
Inspired by natural cryptic halogenation in -bond formation, this study developed a synthetic approach combining biocatalytic bromination with transition-metal-catalyzed cross-coupling. Using the cyanobacterial VHPO, a robust and sustainable bromination-arylation cascade was created. Genetic modifications allowed enzyme immobilization, enhancing the compatibility between biocatalysis and chemocatalysis.
View Article and Find Full Text PDFActivation of caged functional RNAs by an oxidative transformation.
Chembiochem
December 2024
University of Minnesota, Department of Genetics, Cell Biology, and Development, MCB 5-130, 420 Washington Avenue SE, 55455, Minneapolis, UNITED STATES OF AMERICA.
RNA exhibits remarkable capacity as a functional polymer, with broader catalytic and ligand-binding capability than previously thought. Despite this, the low side chain diversity present in nucleic acids (two purines and two pyrimidines) relative to proteins (20+ side chains of varied charge, polarity, and chemical functionality) limits the capacity of functional RNAs to act as environmentally responsive polymers, as is possible for peptide-based receptors and catalysts. Here we show that incorporation of the modified nucleobase 2-thiouridine (2sU) into functional (aptamer and ribozyme) RNAs produces functionally inactivated polymers that can be activated by oxidative treatment.
View Article and Find Full Text PDFIncorporating spatial information in deep learning parameter estimation with application to the intravoxel incoherent motion model in diffusion-weighted MRI.
Med Image Anal
November 2024
Department of Radiology and Nuclear Medicine, St. Olav's University Hospital, Trondheim, Norway; Department of Circulation and Medical Imaging, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
In medical image analysis, the utilization of biophysical models for signal analysis offers valuable insights into the underlying tissue types and microstructural processes. In diffusion-weighted magnetic resonance imaging (DWI), a major challenge lies in accurately estimating model parameters from the acquired data due to the inherently low signal-to-noise ratio (SNR) of the signal measurements and the complexity of solving the ill-posed inverse problem. Conventional model fitting approaches treat individual voxels as independent.
View Article and Find Full Text PDFHarnessing Microbial Signal Transduction Systems in Natural and Synthetic Consortia for Biotechnological Applications.
Biotechnol Appl Biochem
December 2024
Department of Chemical Engineering, Guangdong Technion-Israel Institute of Technology (GTIIT), Shantou, Guangdong, China.
Signal transduction is crucial for communication and cellular response in microbial communities. Consortia rely on it for effective communication, responding to changing environmental conditions, establishing community structures, and performing collective behaviors. Microbial signal transduction can be through quorum sensing (QS), two-component signal transduction systems, biofilm formation, nutrient sensing, chemotaxis, horizontal gene transfer stress response, and so forth.
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