AI Article Synopsis
- - The study aims to differentiate neurodegenerative diseases by using I-metaiodobenzylguanidine (MIBG) and evaluating the myocardial standardized uptake value (SUV) for accuracy.
- - A 17-segment polar map of the heart was created from SPECT-CT images, optimizing the reconstruction conditions to achieve reliable quantitative values, with comparisons made to the heart-to-mediastinum (H/M) ratio.
- - Results indicated that the myocardial SUV gave slightly more accurate quantitative values than the H/M ratio, and using optimal reconstruction parameters allows for consistent assessment of myocardial uptake.
Article Abstract
Purpose: To distinguish neurodegenerative diseases using I-metaiodobenzylguanidine (MIBG). This study proposes a method to evaluate myocardial standardized uptake value (SUV) and assess its accuracy.
Methods: We created a 17-segment polar map of the myocardial region from single-photon emission computed tomography-computed tomography (SPECT-CT) images using a cardioliver phantom simulating the standard uptake of MIBG. We clarified the optimal reconstruction conditions with good repeatability and accuracy of quantitative values and compared them with the H/M ratio. Myocardial SUVs were evaluated from eight normal cases using our method established from the phantom experiment and compared with the H/M ratio.
Results: The optimal numbers of iterations and subsets in OSEM reconstruction were both 10. The optimal full width at half maximum (FWHM) value of the Gaussian filter was 4 pixels. The RCs and %CV of (1) maximum SUV (MaxSUV) and (2) average SUV (AveSUV) were (1) 36.5% and 4.99%, and (2) 33.6% and 4.84%, respectively. The RC and %CV of the H/M ratio was 15.0% and 1.50%, respectively. In clinical cases, average MaxSUV and AveSUV were 8.27 and 7.58, respectively.
Conclusion: Myocardial SUV can provide quantitative values slightly closer to theoretical values than the H/M ratios. Besides, using the optimal reconstruction parameters makes it feasible to quantitatively assess myocardial uptake with good repeatability.
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| http://dx.doi.org/10.6009/jjrt.2023-1235 | DOI Listing |
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