AI Article Synopsis
- Primary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare type of cancer linked to the Epstein-Barr Virus (EBV) and often occurs in people with weakened immune systems.
- There are no established treatment guidelines for CNS-LG, but it shows similarities to aggressive forms of CNS lymphoma, suggesting that intense therapy protocols may be beneficial.
- This report discusses the successful use of high-dose chemotherapy and autologous blood stem cell transplantation in four patients with primary CNS-LG, highlighting a potential new treatment approach based on aggressive CNS lymphoma strategies.
Article Abstract
Primary lymphomatoid granulomatosis of the CNS (CNS-LG) is a rare lymphoid neoplasia associated Epstein-Barr Virus (EBV) and often accompanied by immunodeficiencies. No treatment standards have been defined yet. However, due to often devastating neurologic sequelae and based on similarities to diffuse large B-cell lymphoma, curative treatment requires intensive therapy protocols resembling protocols applied in CNS lymphoma. Here, the clinical courses and treatments of four primary CNS-LG patients in analogy to aggressive CNS-lymphomas including methotrexate, thiotepa, cytarabine, carmustine, and rituximab are presented. This is the first report on high-dose chemotherapy with CNS-directed drugs and autologous blood stem cell transplantation in primary CNS-LG.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10356680 | PMC |
| http://dx.doi.org/10.1007/s00432-022-04531-y | DOI Listing |
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