AI Article Synopsis
- A third dose of the BNT162b2 vaccine significantly boosts antibody levels in healthy individuals.
- Antibody levels were monitored in healthcare workers over one year, showing a notable increase right after the third dose, followed by a gradual decline.
- Despite the decline, antibody levels remained higher than those recorded after previous doses even six months later.
Article Abstract
Background: A third dose of the BNT162b2 SARS-CoV-2 vaccine leads to a significant increase in antibody levels, however, concerns regarding the long-term persistence of this response exist. We assessed the humoral response for one year following vaccination.
Methods: A prospective study among immunocompetent healthcare workers (HCW) who received three doses of BNT162b2. anti-spike antibody titers were measured at six predefined timepoints, from before the second vaccine dose, and up to one year afterwards, which is 4-6 months after the third dose. HCW with a history of SARS-CoV-2 infection were excluded.
Results: Seventy-six HCW had all the six serological measurements. Antibody titers significantly increased shortly following the third vaccine dose, and while declining, remained higher from all previous measurements for up to six months.
Conclusions: A third dose of BNT162b2 leads to a profound humoral response, which remains significantly higher than previous measurements, even after 6 months.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9767891 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2022.12.042 | DOI Listing |
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