Studying human neural function in vivo at the cellular level: Chasing chimeras?

Cell

VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium; IRIBHM, ULB Neuroscience Institute, Université Libre de Bruxelles, B-1070 Belgium. Electronic address:

Published: December 2022

Despite its importance to understanding human brain (dys)function, it has remained challenging to study human neurons in vivo. Recent approaches, using transplantation of human cortical neurons into the rodent brain, offer new prospects for the study of human neural function and disease in vivo, from molecular to circuit levels.

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http://dx.doi.org/10.1016/j.cell.2022.11.020DOI Listing

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