Qualitative research and comprehensive public awareness to nip the transmission of Ebola virus in the bud before it becomes a global threat is fast becoming imperative especially now that the Gambia Ebola virus is mutated. It is therefore necessary to consider and investigate a vector-host transmission model for possible control strategy of this deadly disease. Hence, in this study, we presented a novel and feasible human-bat (host-vector) model which foretells the spread and severity of the Ebola virus from bats to humans to investigate the combined effects of three control strategies viz: (1) allowing specialized and designated agencies to bury deceased from Ebola infection without relatives touching or curdling the remains as usually practiced in most part of Africa as last respect for their departed love ones ( ), (2) systematic and deliberate depopulation of bats in the metropolis (through persecution with pesticide exposure, pre capturing, chemical timber treatment for roosts destruction) to discourage hunting them for food by virtue of their proximity ( ) and (3) immediate treatment of infected individuals in isolation ( ). We established, among others, the endemic equilibrium, disease-free equilibrium, global and local stability, non-negativity, and boundedness of the model to prove the epidemiological feasibility of the model. The reality of the presence of optimal control remarkably influences the dynamics of transmission of the virus and simulated results also confirm the great effect of the combination of the control strategies , and in flattening the curve of Ebola transmission (fig 1 - fig 8). Health workers and policy makers are better informed with fundamental precautions that could help eradicate Ebola from the populace.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9763758PMC
http://dx.doi.org/10.1016/j.heliyon.2022.e12121DOI Listing

Publication Analysis

Top Keywords

ebola virus
16
control strategies
12
optimal control
8
ebola
7
control
6
transmission
5
virus
5
modelling impact
4
impact control
4
strategies transmission
4

Similar Publications

Peptide fibrils as a vaccine: Proof of concept.

J Immunol Methods

January 2025

Institute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, 29 Ulitsa Polytechnicheskaya, St. Petersburg 194064, Russia; Smorodintsev Research Institute of Influenza, Russian Ministry of Health, 15/17 Ulitsa Prof. Popova, St. Petersburg 197376, Russia; Institute of Experimental Medicine, 12 Ulitsa Akademika Pavlova, St. Petersburg 197376, Russia.

Background: Rapid vaccine platforms development is crucial for responding to epidemics and pandemics of emerging infectious diseases, such as Ebola. This study explores the potential of peptide vaccines that self-organize into amyloid-like fibrils, aiming to enhance immunogenicity while considering safety and cross-reactivity.

Methods: We synthesized two peptides, G33 and G31, corresponding to a segment of the Ebola virus GP2 protein, with G33 known to form amyloid-like fibrils.

View Article and Find Full Text PDF

Supervised learning approaches for predicting Ebola-Human Protein-Protein interactions.

Gene

January 2025

Department of Computer and Information Science (IDA), Linköping University, Sweden; Department of Computer Science & Engineering, Techno International New Town, Kolkata, India. Electronic address:

The goal of this research work is to predict protein-protein interactions (PPIs) between the Ebola virus and the host who is at risk of infection. Since there are very limited databases available on the Ebola virus; we have prepared a comprehensive database of all the PPIs between the Ebola virus and human proteins (EbolaInt). Our work focuses on the finding of some new protein-protein interactions between humans and the Ebola virus using some state- of-the-arts machine learning techniques.

View Article and Find Full Text PDF

This study develops an Artificial Neural Network (ANN)-based framework to model the transmission dynamics and long-term disability outcomes of Ebola Virus Disease (EVD). Building on existing deterministic SEIR models, we extend the framework by introducing a disability compartment, capturing the progression of Ebola survivors to chronic health complications, such as post-Ebola syndrome. The proposed model stratifies the population into various epidemiological states, incorporating delays to better reflect the natural progression and intervention strategies associated with EVD.

View Article and Find Full Text PDF

Background: The interactions between virus and the host immune response are nuanced and intricate. The cytokine response arguably plays a central role in dictating the outcome of virus infection, balancing inflammation and healing, which is crucial to resolving infection without destructive immunopathologies.

Summary: Early innate immune responses are key to the generation of a beneficial or detrimental immune response.

View Article and Find Full Text PDF

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning.

Cell Host Microbe

January 2025

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. Electronic address:

Evidence suggests that bats are important hosts of filoviruses, yet the specific species involved remain largely unidentified. Niemann-Pick C1 (NPC1) is an essential entry receptor, with amino acid variations influencing viral susceptibility and species-specific tropism. Herein, we conducted combinatorial binding studies with seven filovirus glycoproteins (GPs) and NPC1 orthologs from 81 bat species.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!