AI Article Synopsis
- - A special drug made from platinum called a prodrug was created, which can be activated by red light to help treat cancer by making it produce a type of oxygen that can kill cancer cells.
- - This drug works well in cancer cells, specifically in some types of cervical and breast cancer, but doesn’t affect healthy cells much, showing it’s safe for normal tissue.
- - It gets to the parts of the cell that are important for energy and stress responses and causes the cancer cells to die by making them stop growing and function poorly.
Article Abstract
A cisplatin-based platinum(iv) prodrug, [Pt(NH)Cl(OH)( )], having as a red-light active boron-dipyrromethene (BODIPY) pendant, was synthesized and characterized and its application as a chemo--photodynamic therapy agent was studied. as the ligand precursor is structurally characterized. The complex displayed an intense absorption band near 650 nm ( ∼ 8.8 × 10 dm mol cm) in 1 : 1 (v/v) DMSO/DPBS. It showed an emission band at 674 nm ( = 630 nm) with a fluorescence quantum yield ( ) value of 0.37. In red light (600-720 nm), it generated singlet oxygen as evidenced from the 1,3-diphenylisobenzofuran (DPBF) titration experiment giving a singlet oxygen quantum yield ( ) value of 0.28 in DMSO. The mechanistic pUC19 DNA photocleavage study and singlet oxygen sensor green (SOSG) assay ascertained its ability to generate singlet oxygen in both extracellular and intracellular media by a type-II photo-process. The complex exhibited high stability in the dark, but on red-light irradiation, it displayed rapid activation in the presence of a reducing environment. It displayed remarkable apoptotic photocytotoxicity with half-maximal inhibitory concentration (IC) ranging from 0.58 to 0.76 μM in human cervical cancer (HeLa) and breast cancer (MCF-7) cells with a respective photo-cytotoxicity index value of >172 and >131. The photodynamic activity was significantly less in non-cancerous human peripheral lung epithelial (HPL1D) cells. The emissive complex showed localization in the mitochondria and endoplasmic reticulum (ER) with a similar Pearson's correlation coefficient value, making it a dual organelle-targeted therapeutic agent. JC-1, fluo-4-AM and annexin V-FITC/propidium iodide assays in HeLa cells showed cellular apoptosis by arresting cells in the sub-G1 phase mitochondrial dysfunction and ER stress.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9749958 | PMC |
| http://dx.doi.org/10.1039/d2md00225f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Chimeric Peptide for Shielding Plant Photosynthetic Systems against Excess Light Stress via Chloroplast-Targeted ROS Quenching.
JACS Au
December 2024
Biomacromolecules Research Team, RIKEN Center for Sustainable Resource Science, Saitama 351-0198, Japan.
The ability to quench reactive oxygen species (ROS) overproduced in plant chloroplasts under light stress conditions is essential for securing plant photosynthetic performance and agricultural yield. Although genetic engineering can enhance plant stress resistance, its widespread application faces limitations due to challenges in successful transformation across plant species and public acceptance concerns. This study proposes a nontransgenic chemical approach using a designed chimeric peptide that scavenges ROS within plant chloroplasts for managing light stress.
View Article and Find Full Text PDFAcquiring stereospecific new pseudosugars: Obtaining rac-decahydro-1,4-epoxynaphthalene-2,3,5,6,7,8-hexaols from the Diels-Alder reaction and investigating their biological effects.
Bioorg Chem
December 2024
Sakarya University, Faculty of Arts and Sciences, Chemistry Department, 54050, Sakarya, Turkey. Electronic address:
In this study, Diels-Alder reaction was performed to sulfolene and endo/exo-diacetate compounds. After a series of reactions, new conduritol A and F analogs containing oxo-bridge and naphthalene rings in their structures were synthesized. To the starting compound, bromination, elimination, singlet oxygen reaction, acetylation, selective oxidation with osmium tetroxide (OsO), and m-chloroperbenzoic acid (m-CPBA), re-acetylation, and finally hydrolysis of the compounds by NH(g)/MeOH reactions were carried out.
View Article and Find Full Text PDFVersatile electrospun cobalt-doped carbon films for rapid antibiotic degradation.
J Environ Manage
December 2024
College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua, 321004, China; Key Laboratory of Watershed Earth Surface Processes and Ecological Security, Zhejiang Normal University, Jinhua, Zhejiang, China. Electronic address:
This study presents a novel approach to water contamination remediation by developing cobalt-doped carbon nanofiber films using electrospun ZIF-67 precursors, aiming to degrade tetracycline hydrochloride (TCH) and other antibiotics. This method uniquely combines the advantages of metal-organic frameworks (MOFs) and electrospinning to enhance catalytic performance, demonstrating significant innovation in environmental catalysis. The research systematically evaluated the impact of various factors on the catalytic activity of carbonized PAN@ZIF-67 films (CPZF), including carbonization temperature, ZIF-67 content, and PMS dosage.
View Article and Find Full Text PDFModification of iron-containing silicate tailings with oxalic acid to develop a long-efficacy utilization peroxymonosulfate-based system for the efficient decomplexation and removal of Cr(III)-ethylenediamine tetraacetic acid.
J Colloid Interface Sci
December 2024
Department of Environmental Science and Engineering, College of Environment and Resources, Xiangtan University, Xiangtan 411105, China.
Ferrous oxalate (FeCO)-based composite has been recognized as an eminent catalyst for Cr(III)-ethylenediamine tetraacetic acid (Cr(III)-EDTA) decomplexation. However, their practical application has been limited by low cycling capacity and an ambiguous mechanism. In this research, a composite catalyst consisting of biotite loaded with nano FeCO (CFS90) was prepared directly from iron-containing silicate tailing.
View Article and Find Full Text PDFExploring Gluconamide-Modified Silica Nanoparticles of Different Sizes as Effective Carriers for Antimicrobial Photodynamic Therapy.
Nanomaterials (Basel)
December 2024
Departamento de Química Física, Facultad de Ciencia y Tecnología, Universidad del País Vasco, UPV-EHU, Apartado 644, 48080 Bilbao, Spain.
Antimicrobial resistance (AMR), a consequence of the ability of microorganisms, especially bacteria, to develop resistance against conventional antibiotics, hampering the treatment of common infections, is recognized as one of the most imperative health threats of this century. Antibacterial photodynamic therapy (aPDT) has emerged as a promising alternative strategy, utilizing photosensitizers activated by light to generate reactive oxygen species (ROS) that kill pathogens without inducing resistance. In this work, we synthesized silica nanoparticles (NPs) of different sizes (20 nm, 80 nm, and 250 nm) functionalized with the photosensitizer Rose Bengal (RB) and a gluconamide ligand, which targets Gram-negative bacteria, to assess their potential in aPDT.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!