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Current Update on Transcellular Brain Drug Delivery. | LitMetric

Current Update on Transcellular Brain Drug Delivery.

Pharmaceutics

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Opposite Air Force Station Palaj, Gandhinagar 382355, Gujarat, India.

Published: December 2022

AI Article Synopsis

Article Abstract

It is well known that the presence of a blood-brain barrier (BBB) makes drug delivery to the brain more challenging. There are various mechanistic routes through which therapeutic molecules travel and deliver the drug across the BBB. Among all the routes, the transcellular route is widely explored to deliver therapeutics. Advances in nanotechnology have encouraged scientists to develop novel formulations for brain drug delivery. In this article, we have broadly discussed the BBB as a limitation for brain drug delivery and ways to solve it using novel techniques such as nanomedicine, nose-to-brain drug delivery, and peptide as a drug delivery carrier. In addition, the article will help to understand the different factors governing the permeability of the BBB, as well as various formulation-related factors and the body clearance of the drug delivered into the brain.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786068PMC
http://dx.doi.org/10.3390/pharmaceutics14122719DOI Listing

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