AI Article Synopsis
- Liver fluke infections are significant global health issues for both animals and humans, with concerns about the introduction of the giant liver fluke in Europe threatening local wildlife like red deer.
- The study aimed to compare liver protein profiles between red deer infected with the liver fluke and healthy controls using advanced proteomics techniques, resulting in the identification of 234 proteins that differed in abundance.
- The research found that liver fluke infection in red deer affects various biological processes, including protein and fat metabolism, oxidative stress response, fibrosis, and cell signaling, which helps deepen our understanding of how parasites interact with their hosts.
Article Abstract
Liver fluke infections are recognised as diseases with worldwide distribution and considerable veterinary and public health importance. The giant liver fluke, , is an important non-native parasite which has been introduced to Europe, posing a threat to the survival of local wildlife populations such as red deer (). The aim of the study was to analyse differences in liver proteomes between -infected and control red deer groups using a label-based high-throughput quantitative proteomics approach. The proteomics analysis identified 234 proteins with differential abundance between the control and infected groups. Our findings showed that infection in this definitive host is associated with changes in the metabolism of proteins and fatty acids, oxidative stress, fibrosis, and signaling pathways. The identified proteins and associated biological pathways represent a valuable contribution to the understanding of host-parasite interactions and the pathogenesis of liver fluke infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786150 | PMC |
| http://dx.doi.org/10.3390/pathogens11121503 | DOI Listing |
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