Effects of with the Ability of 2'-Fucosyllactose Utilization on Intestinal Microecology of Mice.

In breast milk, 2'-Fucosyllactose (2'FL) is the most abundant breast milk oligosaccharide and can selectively promote the proliferation of bifidobacteria. This study aimed to explore the effect of ifidobacterial with different utilization capacities of 2'FL on the intestinal microecology of mice. Furthermore, the effects of ifidobacterial with different 2'FL utilization capabilities on mice gut microbiota under the competitive pressure of 2'FL as a carbon source were explored. Compared with the control group, 2'FL, () M130R01M51 + 2'FL, . subsp. CCFM752, and CCFM752 + 2'FL treatments significantly decreased the food intake. Moreover, the water intake, body weight, and fecal water content in all groups showed no significant difference compared with the control group. The combination of subsp. CCFM752 and 2'FL can significantly increase the levels of pro-inflammatory and anti-inflammatory factors. M130R01M51 and mixed strains combined with 2'FL significantly increased the contents of acetic acid and isobutyric acid. The results showed that M130R01M51, FHuNCS6M1, subsp. CCFM752, and subsp. SDZC2M4 combined with 2'FL significantly increased the species richness of the gut microbiota. Moreover, subsp. CCFM752 and subsp. SDZC2M4 significantly increased the abundance of and , respectively. In conclusion, exploring the impact on intestinal microecology can provide theoretical guidance for the development of personalized prebiotics for different bifidobacteria, which has the potential to improve the ecological imbalance of infant gut microbiota.