In Vitro and In Silico Pharmacological and Cosmeceutical Potential of Ten Essential Oils from Aromatic Medicinal Plants from the Mascarene Islands.

In this study, 10 essential oils (EOs), from nine plants (, , , , , , , , and ) were assessed for their antimicrobial, antiaging and antiproliferative properties. While only , (MIC: 0.50 mg/mL) and (MIC: 2 mg/mL) EOs showed activity against , all EOs except S. samarangense EO demonstrated activity against (MIC: 0.125-0.50 mg/mL). The EOs were either fungistatic or fungicidal against one or both tested Candida species with minimum inhibitory/fungicidal concentrations of 0.016-32 mg/mL. The EOs also inhibited one or both key enzymes involved in skin aging, elastase and collagenase (IC: 89.22-459.2 µg/mL; 0.17-0.18 mg/mL, respectively). Turmerone, previously identified in the EO, showed the highest binding affinity with the enzymes (binding energy: -5.11 and -6.64 kcal/mol). Only leaf, , , , , and EOs were cytotoxic to the human malignant melanoma cells, UCT-MEL1 (IC: 88.91-277.25 µg/mL). All the EOs, except EO, were also cytotoxic to the human keratinocytes non-tumorigenic cells, HaCat (IC: 33.73-250.90 µg/mL). Altogether, some interesting therapeutic properties of the EOs of pharmacological/cosmeceutical interests were observed, which warrants further investigations.