This work aims to assess both experimentally and analytically the fracture behavior of rock specimens containing sharp V-notches (SV-notches) subjected to mixed mode I/II loading. To this end, firstly, several mixed mode fracture tests were conducted on Brazilian disk specimens weakened by an SV-notch (SVNBD sample), performed in their corresponding center and with various notch opening angles. Secondly, the fracture resistance of the tested samples was predicted using a criterion named MTS-FEM. This approach is based on the maximum tangential stress (MTS) criterion, in which the tangential stress is determined from the finite element method (FEM). Additionally, in the present research, the required critical distance is calculated directly from finite element analyses performed on cracked samples. Comparing the experimental results and the analytical predictions, it is shown that the fracture curves obtained from the MTS-FEM criterion are in agreement with the experimental results. These results are achieved without the need for the calculation of stress series expansion coefficients, as an additional advantage of the proposed approach.
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http://dx.doi.org/10.3390/ma15248779 | DOI Listing |
ISA Trans
January 2025
School of Automation, Nanjing University of Science and Technology, Nanjing, 210094, China. Electronic address:
The paper addresses the issue of decentralized control with positivity constraint for impulsive interconnected switched positive systems (IISPSs) with mixed time-varying delays coexisting in the state term and the interconnection term under mode-dependent minimum dwell time (MDMDT) switching. Firstly, a positivity criterion of IISPSs is given from the aspect of sufficiency and necessity. Next, through adopting a new discretized linear copositive Lyapunov-Krasovskii functional approach, a sufficient stability criterion of IISPSs under MDMDT constraint is presented.
View Article and Find Full Text PDFAnal Chim Acta
February 2025
Department of Chemistry, University of Waterloo, Waterloo, ON, Canada. Electronic address:
Background: Normothermic ex situ heart perfusion (ESHP) has emerged as a valid modality for advanced cardiac allograft preservation and conditioning prior to transplantation though myocardial function declines gradually during ESHP thus limiting its potential for expanding the donor pool. Recently, the utilization of dialysis has been shown to preserve myocardial and coronary vasomotor function. Herein, we sought to determine the changes in myocardial metabolism that could support this improvement.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
DPP4 is an enzyme with multiple natural substrates and probable involvement in various mechanisms. It constitutes a drug target for the treatment of diabetes II, although, also related to other disorders. While a number of drugs with competitive inhibitory action and covalent binding capacity are available, undesired side effects exist partly attributed to drug kinetics, and research for finding novel, potent, and safer compounds continues.
View Article and Find Full Text PDFMaterials (Basel)
January 2025
Department of Mechanical Engineering, Kunsan National University, Gunsan-si 54150, Republic of Korea.
The key structural components of a wind turbine blade, such as the skin, spar cap, and shear web, are fabricated from fiber-reinforced composite materials. The spar, predominantly manufactured via resin infusion-a process of resin injection and curing in carbon fibers-is prone to initial defects, such as pores, wrinkles, and delamination. This study suggests employing the pultrusion technique for spar production to consistently obtain a uniform cross-section and augment the reliability of both the manufacturing process and the design.
View Article and Find Full Text PDFMicroorganisms
January 2025
Department of Food Science & Human Nutrition, University of Illinois, Urbana, IL 61801, USA.
Many infants consume both human milk and infant formula (mixed-fed); however, few studies have investigated how mixed feeding affects the gut microbiome composition and metabolic profiles compared to exclusive breastfeeding or formula feeding. Herein, how delivery mode and early nutrition affect the microbiome and metabolome of 6-week-old infants in the STRONG Kids2 cohort was investigated. Fecal samples were collected from exclusively breastfed (BF; n = 25), formula-fed (FF; n = 25) or mixed-fed (MF; n = 25) participants.
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