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Lipid Handling Protein Gene Expression in Colorectal Cancer: CD36 and Targeting miRNAs. | LitMetric

AI Article Synopsis

  • The study investigates the roles of specific genes (CD36 and FASN) and miRNAs in the reprogramming of lipid metabolism in colorectal cancer (CRC) by analyzing 39 paired tumor and surrounding tissues alongside normal samples.
  • Results showed a significant decrease in gene expression of CD36, FASN, and two fatty acid transporters (SLC27A3 and SLC27A4) in CRC tissues, while glypican 4 (GPC4) remained unchanged.
  • Notably, miR-27a-3p was found to be upregulated in tumors, contrasting with the downregulation of CD36, particularly in patients with lymph node metastasis, highlighting potential therapeutic targets linked to fatty acid

Article Abstract

The reprogramming of lipid metabolism has been highlighted in colorectal cancer (CRC) studies, suggesting a critical role for the scavenger receptor CD36 and fatty acid synthase (FASN) in this malignancy. In this study, we analyzed the gene expression levels of CD36, FASN, the cell surface glypican 4 (GPC4), and the two transporters SLC27A3 and SLC27A4 in 39 paired tumoral and peritumoral tissues from patients with CRC compared with 18 normal colonic mucosae. Moreover, the levels of seven miRNAs targeting CD36 and most of the analyzed genes were evaluated. We found a significant impairment of the expression of all the analyzed genes except GPC4 as well as the differential expression of miR-16-5p, miR-26b-5p, miR-107, miR-195-5p, and miR-27a-3p in the colonic mucosa of CRC patients. Interestingly, CD36 and miR-27a-3p were downregulated and upregulated, respectively, in tumoral tissues compared to peritumoral and control tissues, with a significant negative correlation in the group of patients developing lymph node metastasis. Our results sustain the relationship between CRC and fatty acid metabolism and emphasize the importance of related miRNAs in developing new therapeutic strategies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786157PMC
http://dx.doi.org/10.3390/life12122127DOI Listing

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