AI Article Synopsis
- Sperm carries genetic material from the father and can also have special markers that help in making the embryo grow properly.
- Recent research showed that small noncoding RNA (sncRNA) in sperm changes as the sperm moves from the testicles to the epididymis, which could affect how the baby develops.
- The study looks at how these changes in sperm could lead to infertility in men and possibly health problems in their children, and how this info might help with advanced reproductive methods.
Article Abstract
Apart from the paternal half of the genetic material, the male gamete carries assorted epigenetic marks for optimal fertilization and the developmental trajectory for the early embryo. Recent works showed dynamic changes in small noncoding RNA (sncRNA) in spermatozoa as they transit through the testicular environment to the epididymal segments. Studies demonstrated the changes to be mediated by epididymosomes during the transit through the adluminal duct in the epididymis, and the changes in sperm sncRNA content stemmed from environmental insults significantly altering the early embryo development and predisposing the offspring to metabolic disorders. Here, we review the current knowledge on the establishment of the sperm sncRNA transcriptome and their role in male-factor infertility, evidence of altered offspring health in response to the paternal life experiences through sperm sncRNA species and, finally, their implications in assisted reproductive technology in terms of epigenetic inheritance.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779749 | PMC |
| http://dx.doi.org/10.3390/ijms232415716 | DOI Listing |
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