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Re-Emergence of Dengue Serotype 3 in the Context of a Large Religious Gathering Event in Touba, Senegal. | LitMetric

AI Article Synopsis

  • Dengue virus (DENV) first appeared in Senegal in 1979, and since 2017, there have been frequent outbreaks, notably a major one in 2018 during a religious gathering with 263 confirmed cases.
  • The 2018 outbreak showed co-circulation of dengue serotypes 1 and 3, with a significant presence of DENV-3 linked to Genotype III, which primarily spread from a suspected introduction around mid-2017.
  • Phylogenetic analysis indicated close genetic relationships among DENV-3 strains across West African countries, underscoring the virus's regional spread due to events like mass gatherings and the effectiveness of using mobile laboratories for quick diagnostics during outbreaks.

Article Abstract

Dengue virus (DENV) was detected in Senegal in 1979 for the first time. Since 2017, unprecedented frequent outbreaks of DENV were noticed yearly. In this context, epidemiological and molecular evolution data are paramount to decipher the virus diffusion route. In the current study, we focused on a dengue outbreak which occurred in Senegal in 2018 in the context of a large religious gathering with 263 confirmed DENV cases out of 832 collected samples, including 25 life-threatening cases and 2 deaths. It was characterized by a co-circulation of dengue serotypes 1 and 3. Phylogenetic analysis based on the gene revealed that the main detected serotype in Touba was DENV-3 and belonged to Genotype III. Bayesian phylogeographic analysis was performed and suggested one viral introduction around 2017.07 (95% HPD = 2016.61-2017.57) followed by cryptic circulation before the identification of the first case on 1 October 2018. DENV-3 strains are phylogenetically related, with strong phylogenetic links between strains retrieved from Burkina Faso and other West African countries. These phylogenetic data substantiate epidemiological data of the origin of DENV-3 and its spread between African countries and subsequent diffusion after religious mass events. The study also highlighted the usefulness of a mobile laboratory during the outbreak response, allowing rapid diagnosis and resulting in improved patient management.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779395PMC
http://dx.doi.org/10.3390/ijerph192416912DOI Listing

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