AI Article Synopsis
- The study investigates how fasting and refeeding affect muscle growth and phenotype in fish, specifically focusing on pacus, a species commonly farmed.
- Researchers conducted a meta-analysis to identify genes that play a role in muscle adaptation during these food availability changes.
- They found that different fasting and refeeding durations influenced the expression of genes related to muscle protection and energy conservation, highlighting the importance of these factors in aquaculture practices.
Article Abstract
The regulation of the fish phenotype and muscle growth is influenced by fasting and refeeding periods, which occur in nature and are commonly applied in fish farming. However, the regulators associated with the muscle responses to these manipulations of food availability have not been fully characterized. We aimed to identify novel genes associated with fish skeletal muscle adaptation during fasting and refeeding based on a meta-analysis. Genes related to translational and proliferative machinery were investigated in pacus () subjected to fasting (four and fifteen days) and refeeding (six hours, three and fifteen days). Our results showed that different fasting and refeeding periods modulate the expression of the genes , , , and . These alterations can indicate the possible protection of the muscle phenotype, in addition to adaptive responses that prioritize energy and substrate savings over cell division, a process regulated by . Our study reveals the potential of meta-analysis for the identification of muscle growth regulators and provides new information on muscle responses to fasting and refeeding in fish that are of economic importance to aquaculture.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778430 | PMC |
| http://dx.doi.org/10.3390/genes13122378 | DOI Listing |
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