While genomic selection (GS) began revolutionizing plant breeding when it was proposed around 20 years ago, its practical implementation is still challenging as many factors affect its accuracy. One such factor is the choice of the statistical machine learning method. For this reason, we explore the tuning process under a multi-trait framework using the Gaussian kernel with a multi-trait Bayesian Best Linear Unbiased Predictor (GBLUP) model. We explored three methods of tuning (manual, grid search and Bayesian optimization) using 5 real datasets of breeding programs. We found that using grid search and Bayesian optimization improve between 1.9 and 6.8% the prediction accuracy regarding of using manual tuning. While the improvement in prediction accuracy in some cases can be marginal, it is very important to carry out the tuning process carefully to improve the accuracy of the GS methodology, even though this entails greater computational resources.
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http://dx.doi.org/10.3390/genes13122279 | DOI Listing |
J Chem Phys
January 2025
Department of Chemistry, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
We present an algorithm that combines quantum scattering calculations with probabilistic machine-learning models to predict quantum dynamics rate coefficients for a large number of state-to-state transitions in molecule-molecule collisions much faster than with direct solutions of the Schrödinger equation. By utilizing the predictive power of Gaussian process regression with kernels, optimized to make accurate predictions outside of the input parameter space, the present strategy reduces the computational cost by about 75%, with an accuracy within 5%. Our method uses temperature dependences of rate coefficients for transitions from the isolated states of initial rotational angular momentum j, determined via explicit calculations, to predict the temperature dependences of rate coefficients for other values of j.
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January 2025
Electronics and Communication Engineering, Rajiv Gandhi University, Rono Hills, Doimukh, ITANAGAR, Itanagar, Arunachal Pradesh, 791112, INDIA.
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View Article and Find Full Text PDFPlants (Basel)
December 2024
School of Data Science and Artificial Intelligence, Jilin Engineering Normal University, Changchun 130052, China.
The precise identification of maize kernel varieties is essential for germplasm resource management, genetic diversity conservation, and the optimization of agricultural production. To address the need for rapid and non-destructive variety identification, this study developed a novel interpretable machine learning approach that integrates low-field nuclear magnetic resonance (LF-NMR) with morphological image features through an optimized support vector machine (SVM) framework. First, LF-NMR signals were obtained from eleven maize kernel varieties, and ten key features were extracted from the transverse relaxation decay curves.
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January 2025
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
Investigating the relationship, particularly the lead-lag effect, between time series is a common question across various disciplines, especially when uncovering biological processes. However, analyzing time series presents several challenges. Firstly, due to technical reasons, the time points at which observations are made are not at uniform intervals.
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November 2024
Clinical Omics Institute, Kyungpook National University, Daegu 41405, Republic of Korea.
Cervical cancer is a significant health challenge, yet it can be effectively prevented through early detection. Cytology-based screening is critical for identifying cancerous and precancerous lesions; however, the process is labor-intensive and reliant on trained experts to scan through hundreds of thousands of mostly normal cells. To address these challenges, we propose a novel distribution-augmented approach using contrastive self-supervised learning for detecting abnormal squamous cervical cells from cytological images.
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