Advances in Production of Hydroxycinnamoyl-Quinic Acids: From Natural Sources to Biotechnology.

Antioxidants (Basel)

Bioprocess Research Centre, Faculty of Chemical Technology, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania.

Published: December 2022

AI Article Synopsis

  • Hydroxycinnamoyl-quinic acids (HCQAs) are polyphenol esters created from hydroxycinnamic acids and quinic acid, naturally produced by plants and some microorganisms.
  • HCQAs possess diverse therapeutic benefits including antioxidant, antimicrobial, and anti-inflammatory properties, and they are also used in synthesizing nanoparticles and drugs.
  • The current extraction and synthesis methods are complex and expensive, which limits industrial production, but emerging bioconversion techniques may offer future development opportunities.

Article Abstract

Hydroxycinnamoyl-quinic acids (HCQAs) are polyphenol esters formed of hydroxycinnamic acids and (-)-quinic acid. They are naturally synthesized by plants and some micro-organisms. The ester of caffeic acid and quinic acid, the chlorogenic acid, is an intermediate of lignin biosynthesis. HCQAs are biologically active dietary compounds exhibiting several important therapeutic properties, including antioxidant, antimicrobial, anti-inflammatory, neuroprotective, and other activities. They can also be used in the synthesis of nanoparticles or drugs. However, extraction of these compounds from biomass is a complex process and their synthesis requires costly precursors, limiting the industrial production and availability of a wider variety of HCQAs. The recently emerged production through the bioconversion is still in an early stage of development. In this paper, we discuss existing and potential future strategies for production of HCQAs.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774772PMC
http://dx.doi.org/10.3390/antiox11122427DOI Listing

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Antioxidants (Basel)

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Bioprocess Research Centre, Faculty of Chemical Technology, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania.

Article Synopsis
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  • HCQAs possess diverse therapeutic benefits including antioxidant, antimicrobial, and anti-inflammatory properties, and they are also used in synthesizing nanoparticles and drugs.
  • The current extraction and synthesis methods are complex and expensive, which limits industrial production, but emerging bioconversion techniques may offer future development opportunities.
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