AI Article Synopsis
- Despite advancements in biomedical technologies, cardiovascular disease continues to be the leading cause of death, largely because current treatments overlook the effects of aging.
- A proposed model suggests that cell aging, particularly through processes like telomerase inactivation, leads to tissue changes that contribute to age-related cardiovascular issues affecting various heart and blood vessel cells.
- The model indicates that understanding the connection between risk factors and clinical outcomes can lead to more effective therapies, such as telomerase gene therapy, which may revolutionize treatment in cardiovascular medicine.
Article Abstract
Despite progress in biomedical technologies, cardiovascular disease remains the main cause of mortality. This is at least in part because current clinical interventions do not adequately take into account aging as a driver and are hence aimed at suboptimal targets. To achieve progress, consideration needs to be given to the role of cell aging in disease pathogenesis. We propose a model unifying the fundamental processes underlying most age-associated cardiovascular pathologies. According to this model, cell aging, leading to cell senescence, is responsible for tissue changes leading to age-related cardiovascular disease. This process, occurring due to telomerase inactivation and telomere attrition, affects all components of the cardiovascular system, including cardiomyocytes, vascular endothelial cells, smooth muscle cells, cardiac fibroblasts, and immune cells. The unified model offers insights into the relationship between upstream risk factors and downstream clinical outcomes and explains why interventions aimed at either of these components have limited success. Potential therapeutic approaches are considered based on this model. Because telomerase activity can prevent and reverse cell senescence, telomerase gene therapy is discussed as a promising intervention. Telomerase gene therapy and similar systems interventions based on the unified model are expected to be transformational in cardiovascular medicine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775230 | PMC |
| http://dx.doi.org/10.3390/biology11121768 | DOI Listing |
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