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Anti-Inflammatory Effects of Geniposidic Acid on -Induced Periodontitis in Mice. | LitMetric
Periodontal disease is predominantly caused by the pathogenic bacterium that produces inflammation-inducing factors in the host. is a plant native to China that has been reported to reduce blood pressure, promote weight loss, and exhibit anti-inflammatory effects. Geniposidic acid (GPA) is the major component of . Herein, we investigated the effects of GPA on -induced periodontitis by measuring the inflammatory responses in human gingival epithelial cells (HGECs) after stimulation and GPA addition in a -induced periodontitis mouse model. We found that GPA addition suppressed interleukin (IL)-6 mRNA induction (33.8% suppression), IL-6 production (69.2% suppression), toll-like receptor (TLR) 2 induction, and mitogen-activated protein kinase (MAPK) phosphorylation in HGECs stimulated by Inoculation of mice with GPA inhibited -induced alveolar bone resorption (25.6% suppression) by suppressing IL-6 and TLR2 production in the serum and gingiva. GPA suppressed osteoclast differentiation of bone marrow cells induced by M-CSF and sRANKL in mice (56.7% suppression). GPA also suppressed the mRNA expression of OSCAR, NFATc1, c-Fos, cathepsin K, and DC-STAMP. In summary, GPA exerts an anti-inflammatory effect on periodontal tissue and may be effective in preventing periodontal disease.
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