AI Article Synopsis
- Oral squamous cell carcinoma (OSCC) is a common cancer, but the exact mechanisms affecting the cell cycle in OSCC are not fully understood, prompting this study to investigate the roles of specific genes in patients.
- The study involved 88 Polish patients, with gene expression analyzed using quantitative reverse transcription PCR, but results showed no significant differences in gene expression between tumor and margin samples, except for a notable expression increase in G2 tumors compared to G1 tumors.
- The findings suggest that gene expression changes may not significantly influence OSCC development, indicating a need for further research to explore their potential role in tumor invasiveness and progression.
Article Abstract
Background: Oral squamous cell carcinoma (OSCC) is one of the most commonly detected neoplasms worldwide. Not all mechanisms associated with cell cycle disturbances are known in OSCC. Examples of genes involved in the control of the cell cycle are , , and . The aim of this study was to examine the possible association between , , and mRNA expression and influence on clinical variables.
Methods: The study group consisted of 88 Polish patients. The gene expression levels were assessed by quantitative reverse transcription PCR.
Results: We found no statistically significant differences in the expression level of , , and genes in tumour samples compared to margin samples. No association was found between the gene expression levels and clinical parameters, except . The patients with G2 tumours had a significantly higher gene expression level of than patients with low-grade G1 tumours.
Conclusions: We have not demonstrated that a change in expression profiles of genes has a significant impact on the pathogenesis of OSCC. It may also be useful to conduct further studies on the use of expression profile changes as a factor to describe the invasiveness and dynamics of OSCC development.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775533 | PMC |
| http://dx.doi.org/10.3390/biomedicines10123011 | DOI Listing |
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