The paper presents the results of the studies performed to establish the effect of the mixtures between limonene and clotrimazole against microbial pathogens involved in dermatological diseases, such as , , and . Preliminary data obtained from the studies performed in microplates revealed a possible synergism between the mixture of clotrimazole and limonene for . Studies performed "in silico" with programs such as CLC Drug Discovery Workbench and MOLEGRO Virtual Docker, gave favorable scores for docking each compound on a specific binding site for each microorganism. The tests performed for validation, with the clotrimazole (0.1%) and different sources of limonene (1.9% citrus essential oils), showed a synergistic effect on in the case of the mixtures between clotrimazole and the essential oils of or . The studies performed on MRSA showed a synergistic effect between clotrimazole and the essential oils obtained from , , or . In the case of , essential oils and clotrimazole used alone did not exhibit antimicrobial activities, but the mixtures between clotrimazole and the essential oils of or exhibited a synergistic antimicrobial effect.
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| http://dx.doi.org/10.3390/antibiotics11121816 | DOI Listing |
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