AI Article Synopsis
- Biofilms consist of coordinated clusters of cells that are resistant to harsh conditions, making infections difficult to treat due to their chronic nature and growing antibiotic resistance.
- Many microbial infections stem from interactions among multiple species, like in chronic wounds, ear infections, tooth decay, and cystic fibrosis.
- The review highlights the importance of studying these polymicrobial interactions through advanced models and metagenomics to improve therapeutic strategies against biofilm-related infections.
Article Abstract
Biofilms are population of cells growing in a coordinated manner and exhibiting resistance towards hostile environments. The infections associated with biofilms are difficult to control owing to the chronicity of infections and the emergence of antibiotic resistance. Most microbial infections are contributed by polymicrobial or mixed species interactions, such as those observed in chronic wound infections, otitis media, dental caries, and cystic fibrosis. This review focuses on the polymicrobial interactions among bacterial-bacterial, bacterial-fungal, and fungal-fungal aggregations based on and models and different therapeutic interventions available for polymicrobial biofilms. Deciphering the mechanisms of polymicrobial interactions and microbial diversity in chronic infections is very helpful in anti-microbial research. Together, we have discussed the role of metagenomic approaches in studying polymicrobial biofilms. The outstanding progress made in polymicrobial research, especially the model systems and application of metagenomics for detecting, preventing, and controlling infections, are reviewed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774821 | PMC |
| http://dx.doi.org/10.3390/antibiotics11121731 | DOI Listing |
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