Anticancer, Antimicrobial, and Antioxidant Activities of Organodiselenide-Tethered Methyl Anthranilates.

Biomolecules

Chemistry Department, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.

Published: November 2022

Novel methyl anthranilate-based organodiselenide hybrids were synthesized, and their chemical structures were confirmed by state-of-the-art spectroscopic techniques. Their antimicrobial properties were assessed against , , and microbial strains. Moreover, the antitumor potential was estimated against liver and breast carcinomas, as well as primary fibroblast cell lines. The and strains were more sensitive than toward the OSe compounds. Interestingly, methyl 2-amino-5-(methylselanyl) benzoate () showed similar antifungal activity to the standard drug clotrimazole (IA% = 100%) and manifested promising antibacterial activity against (IA% = 91.3%) and (IA% = 90.5%). Furthermore, the minimum inhibitory concentration experiments confirmed the antimicrobial activity of the OSe , which in turn was comparable to clotrimazole and ampicillin drugs. Interestingly, the anticancer properties were more pronounced in the HepG2 cells. The OSe was the most cytotoxic (IC = 3.57 ± 0.1 µM), even more than the Adriamycin drug (IC = 4.50 ± 0.2 µM), and with therapeutic index (TI) 17 proposing its potential selectivity and safety. Additionally, OSe compounds and dimethyl 5,5'-diselanediylbis(2-aminobenzoate) () exhibited promising antioxidants in the 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro assays with 96%, 92%, 91%, and 86% radical scavenging activities compared to 95% by vitamin C in the DPPH and ABTS assays, respectively. These results point to promising antimicrobial, anticancer, and antioxidant activities of OSe and and warrant further studies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775310PMC
http://dx.doi.org/10.3390/biom12121765DOI Listing

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