A Compact Control System to Enable Automated Operation of Microfluidic Bioanalytical Assays.

Biosensors (Basel)

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Published: December 2022

We describe a control system for operating valve-enabled microfluidic devices and leverage this control system to carry out a complex workflow of plasma separation from 8 μL of whole blood followed by on-chip mixing of plasma with assay reagents for biomarker detection. The control system incorporates pumps, digital pressure sensors, a microcontroller, solenoid valves and off-the-shelf components to deliver high and low air pressure in the desired temporal sequence to meter fluid flow and actuate microvalves. Importantly, our control system is portable, which is suitable for operating the microvalve-enabled microfluidic devices in the point-of-care setting.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9775492PMC
http://dx.doi.org/10.3390/bios12121160DOI Listing

Publication Analysis

Top Keywords

control system
20
microfluidic devices
8
system
5
compact control
4
system enable
4
enable automated
4
automated operation
4
operation microfluidic
4
microfluidic bioanalytical
4
bioanalytical assays
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!