AI Article Synopsis
- Alzheimer disease (AD) is the leading cause of dementia globally, but clearer comparisons of the safety and effectiveness of available treatments are still needed.
- This study will focus on systematic reviews of randomized controlled trials involving elderly AD patients, examining both pharmacotherapies and non-pharmacotherapies to assess their effectiveness in improving various patient outcomes.
- Ultimately, the research aims to identify the most effective treatments for AD, which will aid clinicians in making better treatment decisions and enhancing patient care.
Article Abstract
Background: Alzheimer disease (AD) is the most common cause of dementia worldwide. Despite the publication of numerous systematic reviews and meta-analyses that have summarized the evidence associated with pharmacotherapies (PTs) and non-pharmacotherapies (NPTs) for the wide range of interventions available for AD treatment, their comparative safety and efficacy remains insufficiently defined.
Methods: Systematic reviews of randomized controlled trials (RCTs) will be selected according to the following criteria: conducted in elderly patients aged 60 years or older with AD living in community or institutionalized settings, applied pairwise meta-analysis (PMA) or network meta-analysis (NMA) approaches providing pooled relative treatment effects for at least 1 pair of PTs or NPTs, and providing at least 1 of the following outcomes for patients/caregivers: cognitive, functional status, behavior, quality of life (QoL), and caregiver stress or burden. All article screening, data extraction, and risk of bias assessment will be completed independently by 2 reviewers. Relative treatment rankings will be reported with mean ranks and surface under the cumulative ranking curves.
Results And Conclusion: We will determine the most efficacious treatment strategies for AD patients from the most highly ranked treatments. These results will help to guide clinical decision-making and improve patient care.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9771260 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000032382 | DOI Listing |
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