AI Article Synopsis
- The gut microbiome plays a vital role in maintaining host health, but excessive antibiotic use can disrupt this balance and lead to health issues.
- This study investigates how the broad-spectrum antibiotic colistin affects the microbiome in various gastrointestinal regions of piglets using advanced metagenome analyses.
- Findings show that colistin significantly alters the composition of gut microbiota, increasing certain bacterial abundances while decreasing others, which has implications for animal health and potential effects on human public health.
Article Abstract
The gut microbiome exerts important functions on host health maintenance, whereas excessive antibiotic use may cause gut flora dysfunction resulting in serious disease and dysbiosis. Colistin is a broad-spectrum antibiotic with serious resistance phenomena. However, it is unclear whether colistin alters the gastrointestinal tract microbiome in piglets. In this study, 16s rDNA-based metagenome analyses were used to assess the effects of colistin on the modification of the piglet microbiome in the stomach, duodenum, jejunum, cecum, and feces. Both α- and β-diversity indices showed that colistin modified microbiome composition in these gastrointestinal areas. In addition, colistin influenced microbiome composition at the phylum and genus levels. At the species level, colistin upregulated , , , , and abundance, but downregulated , , , , , , and abundance in stomachs. Colistin-fed piglets showed an increased abundance of , , , and , but , , , , and abundance was decreased in the cecum. In feces, colistin promoted , , , , and abundance when compared with controls. Taken together, colistin modified the microbiome composition of gastrointestinal areas in piglets. This study provides new clinical rationalization strategies for colistin on the maintenance of animal gut balance and human public health.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787881 | PMC |
| http://dx.doi.org/10.3390/vetsci9120666 | DOI Listing |
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